MicroRNA expression at diagnosis adds relevant prognostic information to molecular categorization in patients with intermediate-risk cytogenetic acute myeloid leukemia
| Autor: | Inmaculada Heras, M.P. Queipo de Llano, Marina Díaz-Beyá, Tania Díaz, Marta Pratcorona, Lourdes Escoda, Rafael F. Duarte, Jordi Esteve, Jordi Sierra, J. Bargay, Josep F. Nomdedeu, David Gallardo, Salut Brunet, Alfons Navarro, Josep-Maria Ribera, Rut Tejero, M Monzo, Mar Tormo |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Risk Cancer Research NPM1 Myeloid Adolescent Disease miR-409-3p Biology Bioinformatics miR-135a AML hemic and lymphatic diseases microRNA CEBPA medicine Humans miRNA Aged Homeodomain Proteins miR-644 Myeloid leukemia miR-196b Hematology Middle Aged medicine.disease Prognosis Gene Expression Regulation Neoplastic Leukemia Leukemia Myeloid Acute MicroRNAs medicine.anatomical_structure Oncology Cohort Female Nucleophosmin |
| Zdroj: | LEUKEMIA r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 1476-5551 0887-6924 |
| Popis: | Acute myeloid leukemia (AML) is a heterogeneous disease, and optimal treatment varies according to cytogenetic risk factors and molecular markers. Several studies have demonstrated the prognostic importance of microRNAs (miRNAs) in AML. Here we report a potential association between miRNA expression and clinical outcome in 238 intermediate-risk cytogenetic AML (IR-AML) patients from 16 institutions in the CETLAM cooperative group. We first profiled 670 miRNAs in a subset of 85 IR-AML patients from a single institution and identified 10 outcome-related miRNAs. We then validated these 10 miRNAs by individual assays in the total cohort and confirmed the prognostic impact of 4 miRNAs. High levels of miR-196b and miR-644 were independently associated with shorter overall survival, and low levels of miR-135a and miR-409-3p with a higher risk of relapse. Interestingly, miR-135a and miR-409-3p maintained their independent prognostic value within the unfavorable molecular subcategory (wild-type NPM1 and CEBPA and/or FLT3-ITD), and miR-644 retained its value within the favorable molecular subcategory. miR-409-3p, miR-135a, miR-196b and mir-644 arose as prognostic markers for IR-AML, both overall and within specific molecular subgroups. |
| Databáze: | OpenAIRE |
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