The incidence of newly diagnosed secondary cancer; sub-analysis the prospective study of the second-look procedure for transoral surgery in patients with T1 and T2 head and neck cancer
| Autor: | Takashi Wada, Hideaki Takahashi, Daisuke Sano, Goshi Nishimura, Takashi Hatano, Yasuhiro Arai, Yosuke Kitani, Nobuhiko Oridate, Kentaro Takada |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Disease 03 medical and health sciences 0302 clinical medicine Surgical oncology Internal medicine medicine Humans Prospective Studies Prospective cohort study Survival rate Hypopharyngeal Neoplasms business.industry Incidence Incidence (epidemiology) Head and neck cancer Neoplasms Second Primary Hypopharyngeal cancer Hematology General Medicine Odds ratio medicine.disease 030104 developmental biology Oncology Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell Surgery business |
| Zdroj: | International Journal of Clinical Oncology. 26:59-65 |
| ISSN: | 1437-7772 1341-9625 |
| Popis: | Our prospective study of patients with early T-stage head and neck cancer indicated a high incidence of newly diagnosed secondary malignancies during the follow-up period. We aimed to determine the incidence rate and risk factors of secondary malignancies in early-stage head and neck cancer patients. We sub-analyzed the patient data of a previous study focusing on secondary cancer incidence. The endpoints were statistical analyses of risk factors and survival and incidence rates. The incidence rate of secondary cancer was 37%, the crude incidence of second primary cancers was 10.6 per 100 person-years, and the 5 year secondary cancer-free survival rate was 63%. The hypopharynx as the primary site was an independent significant predictive factor (odds ratio 3.96, 95% confidence interval 1.07–14.6, p = 0.039). Early stages of laryngeal, oropharyngeal, and hypopharyngeal cancer had a risk of secondary cancer, especially hypopharyngeal cancer. Attention to the secondary cancer has to be paid during the follow-up period after controlling the early-stage disease. These findings highlight the need for awareness of the incidence of secondary cancer in cases of early-stage primary head and neck cancer. |
| Databáze: | OpenAIRE |
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