Vitamin B(12) in type 2 diabetic patients treated with metformin
| Autor: | José Manuel Ramiro Lozano, José María Calvo Romero |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Drug
Vitamin b Male medicine.medical_specialty endocrine system diseases media_common.quotation_subject Cobalamin Gastroenterology chemistry.chemical_compound Drug treatment Internal medicine Diabetes mellitus medicine Outpatient clinic Humans Hypoglycemic Agents Vitamin B12 media_common Aged business.industry nutritional and metabolic diseases medicine.disease Metformin Vitamin B 12 Cross-Sectional Studies chemistry Diabetes Mellitus Type 2 Female business medicine.drug |
| Zdroj: | Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion. 59(8) |
| ISSN: | 1579-2021 |
| Popis: | Objective To test vitamin B 12 plasma levels in type 2 diabetic patients treated with metformin in our area. Methods A cross-sectional, observational study of consecutive type 2 diabetic patients on drug treatment attending an internal medicine outpatient clinic. Results One hundred and nine patients (81 treated with metformin) were enrolled into the study. Mean time on metformin treatment was 43.5 months and mean drug dose was 1779 mg/day. Patients treated with metformin had significantly lower vitamin B 12 plasma levels (393.5 vs 509 pg/mL, p = 0.0008). Seven (8.6%) of 81 patients treated with metformin and none of the 28 patients not treated with the drug had vitamin B 12 plasma levels lower than 197 pg/mL. No correlation was found between vitamin B 12 plasma levels and metformin treatment time or dosage. Conclusions In type 2 diabetic patients, treatment with metformin is associated to lower vitamin B 12 plasma levels. Vitamin B 12 deficiency associated with metformin is relatively common in our area. |
| Databáze: | OpenAIRE |
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