Regulation of dynamin family proteins by post-translational modifications
| Autor: | Abdur Rahaman, Usha Pallabi Kar, Himani Dey |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Dynamins Mechanism (biology) SUPERFAMILY macromolecular substances General Medicine GTPase Biology Endocytosis General Biochemistry Genetics and Molecular Biology Cell biology 03 medical and health sciences 030104 developmental biology Multigene Family Organelle Posttranslational modification Phosphorylation Animals General Agricultural and Biological Sciences Protein Processing Post-Translational Dynamin |
| Zdroj: | Journal of biosciences. 42(2) |
| ISSN: | 0973-7138 |
| Popis: | Dynamin superfamily proteins comprising classical dynamins and related proteins are membrane remodelling agents involved in several biological processes such as endocytosis, maintenance of organelle morphology and viral resistance. These large GTPases couple GTP hydrolysis with membrane alterations such as fission, fusion or tubulation by undergoing repeated cycles of self-assembly/disassembly. The functions of these proteins are regulated by various post-translational modifications that affect their GTPase activity, multimerization or membrane association. Recently, several reports have demonstrated variety of such modifications providing a better understanding of the mechanisms by which dynamin proteins influence cellular responses to physiological and environmental cues. In this review, we discuss major post-translational modifications along with their roles in the mechanism of dynamin functions and implications in various cellular processes. |
| Databáze: | OpenAIRE |
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