Multiwalled Carbon Nanotubes Inhibit Tumor Progression in a Mouse Model
| Autor: | Iñigo Casafont, Rafael Valiente, Lorena García-Hevia, Mónica L. Fanarraga, Juan C. Villegas, Jesús González, Fidel Fernández |
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| Přispěvatelé: | Universidad de Cantabria |
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Paclitaxel Cell division Biomedical Engineering Pharmaceutical Science Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials Mice chemistry.chemical_compound Tubulin In vivo Cell Line Tumor Animals Melanoma Cancer Drug Carriers Nanotubes Carbon Anti-proliferative Neoplasms Experimental 021001 nanoscience & nanotechnology 0104 chemical sciences Antineoplastic agent chemistry Nanotoxicology Tumor progression Drug delivery Cancer research Nanomedicine Biomimetic 0210 nano-technology Drug carrier |
| Zdroj: | Advanced Healthcare Materials 2016, 5, 1080-1087 |
| ISSN: | 2192-2640 |
| Popis: | Understanding the molecular mechanisms underlying the biosynthetic interactions between particular nanomaterials with specific cells or proteins opens new alternatives in nanomedicine and nanotoxicology. Multiwalled carbon nanotubes (MWCNTs) have long been explored as drug delivery systems and nanomedicines against cancer. There are high expectations for their use in therapy and diagnosis. These filaments can translocate inside cultured cells and intermingle with the protein nanofilaments of the cytoskeleton, interfering with the biomechanics of cell division mimicking the effect of traditional microtubule-binding anti-cancer drugs such as paclitaxel. Here, it is shown how MWCNTs can trigger significant anti-tumoral effects in vivo, in solid malignant melanomas produced by allograft transplantation. Interestingly, the MWCNT anti-tumoral effects are maintained even in solid melanomas generated from paclitaxel-resistant cells. These findings provide great expectation in the development of groundbreaking adjuvant synthetic microtubule-stabilizing chemotherapies to overcome drug resistance in cancer. Acknowledgements: We thank Dr. E. Flahaut for providing the MWCNTs. We are grateful to the Nikon A1R Laser Microscopy Unit of the IDIVAL Institute for the electron microscopy and confocal/time-lapse microscopy, and to M. Aramburu and J. Díaz-Gómez for their help. This work has been supported by the Spanish MINECO and European Union FEDER under Projects ref. PI13/01074 (AES 2013) and MAT2012-38664-C02-01. We especially thank the Fundación Eugenio Rodríguez Pascual (ref “Ayudas de investigación” 2014). |
| Databáze: | OpenAIRE |
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