Lactational High-Fat Diet Exposure Programs Metabolic Inflammation and Bone Marrow Adiposity in Male Offspring

Autor: Ormond A. MacDougald, Carlson Z, Hannah Hafner, Jeremy Clemente, Devika P. Bagchi, Mita Varghese, Eric C. Chang, Kanakadurga Singer, Brigid Gregg, Allen Zhu, Simin Abrishami
Rok vydání: 2019
Předmět:
Blood Glucose
Male
0301 basic medicine
Time Factors
Adipose tissue
Weight Gain
0302 clinical medicine
Bone Marrow
Risk Factors
Lactation
Glucose homeostasis
Medicine
Myeloid Cells
Adiposity
2. Zero hunger
Nutrition and Dietetics
Age Factors
adipose tissue
medicine.anatomical_structure
Maternal Exposure
Female
Inflammation Mediators
lcsh:Nutrition. Foods and food supply
medicine.medical_specialty
Normal diet
Offspring
Adipose tissue macrophages
Nutritional Status
lcsh:TX341-641
030209 endocrinology & metabolism
lactation
Diet
High-Fat
Article
03 medical and health sciences
Sex Factors
Insulin resistance
Overnutrition
developmental programming
Internal medicine
Animals
Obesity
business.industry
nutritional and metabolic diseases
Maternal Nutritional Physiological Phenomena
medicine.disease
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
inflammation
Hyperglycemia
Insulin Resistance
business
metabolism
Biomarkers
Food Science
Zdroj: Nutrients, Vol 11, Iss 6, p 1393 (2019)
Nutrients
Volume 11
Issue 6
ISSN: 2072-6643
DOI: 10.3390/nu11061393
Popis: Overnutrition during critical windows of development plays a significant role in life-long metabolic disease risk. Early exposure to excessive nutrition may result in altered programming leading to increased susceptibility to obesity, inflammation, and metabolic complications. This study investigated the programming effects of high-fat diet (HFD) exposure during the lactation period on offspring adiposity and inflammation. Female C57Bl/6J dams were fed a normal diet or a 60% HFD during lactation. Offspring were weaned onto a normal diet until 12 weeks of age when half were re-challenged with HFD for 12 weeks. Metabolic testing was performed throughout adulthood. At 24 weeks, adipose depots were isolated and evaluated for macrophage profiling and inflammatory gene expression. Males exposed to HFD during lactation had insulin resistance and glucose intolerance as adults. After re-introduction to HFD, males had increased weight gain and worsened insulin resistance and hyperglycemia. There was increased infiltration of pro-inflammatory CD11c+ adipose tissue macrophages, and bone marrow was primed to produce granulocytes and macrophages. Bone density was lower due to enhanced marrow adiposity. This study demonstrates that maternal HFD exposure during the lactational window programs offspring adiposity, inflammation, and impaired glucose homeostasis.
Databáze: OpenAIRE
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