The Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2 in a Pediatric Healthcare Network in the United States

Autor: Rebecca M. Harris, Susan E. Coffin, Xianqun Luan, Leila C Posch, Audrey R. Odom John, Sarah Geoghegan, Jeffrey S. Gerber, Julia S. Sammons, William R Otto, Louis M. Bell
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
medicine.medical_treatment
coronavirus
medicine.disease_cause
Polymerase Chain Reaction
0302 clinical medicine
COVID-19 Testing
Pandemic
Epidemiology
030212 general & internal medicine
Child
Coronavirus
New Jersey
General Medicine
testing
Hospitalization
Infectious Diseases
AcademicSubjects/MED00290
Child
Preschool
Original Article
epidemiology
Female
Coronavirus Infections
medicine.medical_specialty
Adolescent
Pneumonia
Viral
03 medical and health sciences
Betacoronavirus
030225 pediatrics
Internal medicine
medicine
Extracorporeal membrane oxygenation
Humans
Pediatrics
Perinatology
and Child Health
Pandemics
Asthma
Asymptomatic Diseases
Retrospective Studies
Mechanical ventilation
business.industry
Clinical Laboratory Techniques
SARS-CoV-2
COVID-19
Infant
Retrospective cohort study
Pennsylvania
medicine.disease
Pediatrics
Perinatology and Child Health
business
AcademicSubjects/MED00670
Zdroj: Journal of the Pediatric Infectious Diseases Society
ISSN: 2048-7207
2048-7193
Popis: BackgroundUnderstanding the prevalence and clinical presentation of coronavirus disease 2019 in pediatric patients can help healthcare providers and systems prepare and respond to this emerging pandemic.MethodsThis was a retrospective case series of patients tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across a pediatric healthcare network, including clinical features and outcomes of those with positive test results.ResultsOf 7256 unique children tested for SARS-CoV-2, 424 (5.8%) tested positive. Patients aged 18–21 years had the highest test positive rate (11.2%), while those aged 1–5 years had the lowest (3.9%). By race, 10.6% (226/2132) of black children tested positive vs 3.3% (117/3592) of white children. By indication for testing, 21.1% (371/1756) of patients with reported exposures or clinical symptoms tested positive vs 3.8% (53/1410) of those undergoing preprocedural or preadmission testing. Of 424 patients who tested positive for SARS-CoV-2, 182 (42.9%) had no comorbidities, 87 (20.5%) had asthma, and 55 (13.0%) were obese. Overall, 52.1% had cough, 51.2% fever, and 14.6% shortness of breath. Seventy-seven (18.2%) SARS-CoV-2–positive patients were hospitalized, of whom 24 (31.2%) required respiratory support. SARS-CoV-2-targeted antiviral therapy was given to 9 patients, and immunomodulatory therapy to 18 patients. Twelve (2.8%) SARS-CoV-2-positive patients required mechanical ventilation, and 2 patients required extracorporeal membrane oxygenation. Two patients died.ConclusionsIn this large cohort of pediatric patients tested for SARS-CoV-2, the rate of infection was low but varied by testing indication. The majority of cases were mild and few children had critical illness.
Databáze: OpenAIRE
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