Perioperative anaphylaxis to chlorhexidine: Crucial role of in-vitro testing
| Autor: | Angela Rizzi, Eleonora Nucera, A Buonomo, A Aruanno, Manuela Ferraironi, Valter Perilli |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Allergy biology Biguanide medicine.drug_class business.industry chlorhexidine Settore MED/09 - MEDICINA INTERNA Immunology Chlorhexidine General Medicine Perioperative medicine.disease Immunoglobulin E Dermatology Basophil activation anaphylaxis medicine biology.protein Etiology Immunology and Allergy business Anaphylaxis medicine.drug |
| Zdroj: | Asian Pacific journal of allergy and immunology. |
| ISSN: | 0125-877X |
| Popis: | Background Chlorhexidine is a synthetic biguanide with a broad antibacterial activity and has become an important cause of perioperative anaphylaxis. Objective Reactions due to chlorhexidine allergy are usually IgE-mediated. The aim of this report is to demonstrate utility of laboratory in-vitro testing for diagnosis. Methods We report the case of a 36-year old man who experienced severe anaphylaxis during general anesthesia. He underwent skin tests, specific detection of specific IgE to chlorhexidine and basophil activation test (BAT). Results Skin tests gave false positive results due to dermographism. So, on the basis of a clinical reaction to chlorhexidine and positive tests for IgE to chlorexidine and BAT, we assessed the diagnosis of chlorhexidine allergy. Conclusions Physicians should be aware of the role of chlorhexidine in the etiology of perioperative anaphylaxis. In vitro testing such specific IgE and BAT are useful in patient with suspected chlorexidine allergy and limitation to perform skin tests. |
| Databáze: | OpenAIRE |
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