Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats

Autor: Mireille Raccurt, Richard C. Li, David Gozal, Shang Z. Guo, Elara Moudilou, Gérard Morel, Kenneth R. Brittian
Přispěvatelé: Department of Pediatrics, University of Chicago, University of Louiville, Écophysiologie, Comportement, Conservation, Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés (LEHNA), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE), INSERM U365, Faculté de Médecine Laennec, Mécanisme Moléculaire du Diabète (MMD), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), university of louis ville, University of Louis Ville, Equipe 4, Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Louisville-Kosair Children's Hospital Research Institute, Department of Pharmacology and Toxicology, University of Louisville, Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
Vascular Endothelial Growth Factor A
MESH: Hippocampus
MESH: Insulin-Like Growth Factor I
MESH: Anoxia
Growth hormone receptor
MESH: Rats
Sprague-Dawley
Hippocampal formation
Hippocampus
Rats
Sprague-Dawley
chemistry.chemical_compound
sleep disordered breathing
0302 clinical medicine
MESH: Caspase 3
neurocognitive dysfunction
MESH: Animals
Insulin-Like Growth Factor I
Hypoxia
0303 health sciences
Glucose Transporter Type 1
MESH: Heme Oxygenase-1
Caspase 3
General Neuroscience
Intermittent hypoxia
3. Good health
Vascular endothelial growth factor
Vascular endothelial growth factor A
medicine.symptom
MESH: Receptors
Somatotropin
medicine.drug
medicine.medical_specialty
MESH: Rats
[SDV.CAN]Life Sciences [q-bio]/Cancer
Article
03 medical and health sciences
Internal medicine
medicine
Animals
Humans
MESH: Erythropoietin
Maze Learning
Erythropoietin
030304 developmental biology
MESH: Humans
business.industry
MESH: Maze Learning
MESH: Vascular Endothelial Growth Factor A
Receptors
Somatotropin
Hypoxia (medical)
MESH: Male
Rats
Disease Models
Animal
MESH: Cognition Disorders
Endocrinology
chemistry
MESH: Growth Hormone
growth hormone
MESH: Disease Models
Animal
[SDE.BE]Environmental Sciences/Biodiversity and Ecology
business
Cognition Disorders
030217 neurology & neurosurgery
Heme Oxygenase-1
Hormone
MESH: Glucose Transporter Type 1
Zdroj: Neuroscience
Neuroscience, Elsevier-International Brain Research Organization, 2011, 24, pp.196-237. ⟨10.1016/j.neuroscience.2011.08.029⟩
Neuroscience, Elsevier-International Brain Research Organization, 2011, 196, pp.237-50. ⟨10.1016/j.neuroscience.2011.08.029⟩
ISSN: 0306-4522
1873-7544
DOI: 10.1016/j.neuroscience.2011.08.029⟩
Popis: International audience; Sleep disordered breathing (SDB), which is characterized by intermittent hypoxia (IH) during sleep, causes substantial cardiovascular and neurocognitive complications and has become a growing public health problem. SDB is associated with suppression of growth hormone (GH) secretion, the latter being integrally involved in the growth, development, and function of the CNS. Since GH treatment is able to attenuate neurocognitive deficits in a hypoxic-ischemic stroke model, GH, GH receptor (GHR) mRNA expression, and GH protein expression were assessed in rat hippocampus after exposures to chronic sustained hypoxia (CH, 10% O(2)) or IH (10% O(2) alternating with 21% O(2) every 90 s). In addition, the effect of GH treatment (50 μg/kg daily s.c. injection) on erythropoietin (EPO), vascular endothelial growth factor (VEGF), heme oxygenase-1 (HO-1), and GLUT-1 mRNA expression and neurobehavioral function was assessed. CH significantly increased GH mRNA and protein expression, as well as insulin-like growth factor-1 (IGF-1). In contrast, IH only induced a moderate increase in GH mRNA and a slight elevation in GH protein at day 1, but no increases in IGF-1. CH, but not IH, up-regulated GHR mRNA in the hippocampus. IH induced marked neurocognitive deficits compared with CH or room air (RA). Furthermore, exogenous GH administration increased hippocampal mRNA expression of IGF-1, EPO, and VEGF, and not only reduced IH-induced hippocampal injury, but also attenuated IH-induced cognitive deficits. Thus, exogenous GH may provide a viable therapeutic intervention to protect IH-vulnerable brain regions from SDB-associated neuronal loss and associated neurocognitive dysfunction.
Databáze: OpenAIRE
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