Synthesis, characterization and biological evaluation of novel tetrasubsituted Imidazole compounds
| Autor: | Digvijay Pandey, Muhammad Tahir, Sanila Ajmal, Faheem Abbas, khurram shahzad, Mudassar Khadim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Primary (chemistry)
Tetrasubsituted imidazoles synthesis Chemistry One-pot synthesis other Biological activity compound K2 chemistry.chemical_compound Acetic acid antibacterial activity cyclocondensation reaction Organic chemistry Imidazole characterization Benzil Antibacterial activity Ammonium acetate |
| DOI: | 10.5281/zenodo.3901332 |
| Popis: | A new class of tetrasubsituted imidazole based compounds were synthesized using multicomponent one pot synthesis scheme through cyclocondensation reaction of benzil, aromatic primary amines, aldehydes and ammonium acetate in glacial acetic acid. The synthesized compounds have been analyzed and characterized by melting point, color, conductivity method, CHN analysis, FT-IR and UV-Visible. The reaction proceeding was examined by TLC after regular intervals of period. To test biological activity, the synthesized compounds have been examined against various bacterial strains. From the analysis of the antibacterial activity of these synthesized compounds demonstrated that all three imidazole compounds have considerable to significant activity against the strains, and compound K2 was found potent comparatively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|