Codon usage trend in genes associated with obesity
| Autor: | Yoon Shin Cho, Supriyo Chakraborty, Yashmin Choudhury, Yeongseon Ahn, S. B. Paul, Arif Uddin, Parvin A. Barbhuiya |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Bioengineering Biology medicine.disease_cause 01 natural sciences Applied Microbiology and Biotechnology 03 medical and health sciences 010608 biotechnology medicine Humans Test analysis Obesity Selection Genetic Codon Usage Gene Genetics Mutation Computational Biology General Medicine medicine.disease Housekeeping gene 030104 developmental biology Codon usage bias Health care cost Biotechnology |
| Zdroj: | Biotechnology Letters. 42:1865-1875 |
| ISSN: | 1573-6776 0141-5492 |
| Popis: | Obesity is not only a social menace but also an economic burden as it reduces productivity and increases health care cost. We used bioinformatic tools to analyze the CUB of obesity associated genes and compared with housekeeping genes (control) to explore the similarities and differences between two data sets as no work was reported yet. The mean effective number of codons (ENC) in genes associated with obesity and housekeeping gene was 50.45 and 52.03 respectively, indicating low CUB. The relative synonymous codon usage (RSCU) suggested that codons namely CTG and GTG were over-represented in both obesity and housekeeping genes while under-represented codons were TCG, TTA, CTA, CCG, CAA, CGT, ATA, ACG, GTA and GCG in obesity genes and TCG, TTA, CCG, ATA, ACG, GTA, and GCG in housekeeping genes. t test analysis suggested that 11 codons namely TTA (Leu), TTG (Leu), CCG (Pro), CAC (His), CAA (Gln), CAG (Gln), CGT (Arg), AGA (Arg), ATA (Ile), ATT (Ile) and GCG (Ala) were significantly differed (p |
| Databáze: | OpenAIRE |
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