The dialogue between the brain and immune system involves not only the HPA-axis
| Autor: | Konrad Schauenstein, Donald A. Chambers, I. Rinner, Peter M. Liebmann, P. Felsner, R.L. Cohen, Albert Wölfler, J. Westermann, H.S. Haas, R. Stevenson |
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| Rok vydání: | 2000 |
| Předmět: |
Hypothalamo-Hypophyseal System
animal diseases Pituitary-Adrenal System Adrenergic chemical and pharmacologic phenomena Immune receptor Autonomic Nervous System Lymphocyte Activation Autoimmune Diseases Feedback Mice Catecholamines Immune system Rheumatology Afferent medicine Animals Humans biology Excitatory amino-acid transporter Brain biochemical phenomena metabolism and nutrition Acetylcholine Rats Immunology biology.protein bacteria Cholinergic Neuroscience medicine.drug |
| Zdroj: | Zeitschrift für Rheumatologie. 59:II49-II53 |
| ISSN: | 0340-1855 |
| Popis: | Starting out from our previous observations that defects in the immune system – brain feedback predispose to pathogenic immune responses, our interest focusses at the roles of adrenergic/cholinergic neurotransmitters in brain – immune interactions. We have shown in rodent models that 1) both catecholamines and acetylcholine are potent modulators of peripheral immune functions, 2) cholinergic signals are involved in the afferent signalling of the immune system, and 3) lymphocytes not only express functional adrenergic and cholinergic receptors, but synthesize and release neurotransmitters, such as acetylcholine, in quantitative dependence of differentiation and activation. Studies are presently being initiated to investigate the role(s) of these non-neural neurotransmitters within immune tissues, and to explore the relevance of excitatory amino acids as important central neurotransmitters in the brain – immune system dialogue. |
| Databáze: | OpenAIRE |
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