A single coadministration of subeffective doses of ascorbic acid and ketamine reverses the depressive-like behavior induced by chronic unpredictable stress in mice
| Autor: | Isabel Werle, Priscila B. Rosa, Suene Vanessa da Silva Souza, Morgana Moretti, Vivian B. Neis, Ana Lúcia S. Rodrigues, Nicolle Platt |
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| Rok vydání: | 2019 |
| Předmět: |
Single administration
Clinical Biochemistry Combined use Ascorbic Acid Hippocampal formation Pharmacology Toxicology Biochemistry Hippocampus 03 medical and health sciences Behavioral Neuroscience Mice 0302 clinical medicine medicine Hippocampus (mythology) Animals Ketamine Biological Psychiatry Depressive Disorder Major Behavior Animal Chemistry Depression Drug Synergism Ascorbic acid medicine.disease Antidepressive Agents 030227 psychiatry Disease Models Animal Treatment Outcome Hindlimb Suspension Major depressive disorder Antidepressant Drug Therapy Combination Female 030217 neurology & neurosurgery Locomotion Stress Psychological medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 187 |
| ISSN: | 1873-5177 |
| Popis: | In this study, we investigated the ability of a single coadministration of subeffective doses of ascorbic acid and ketamine to reverse the depressive-like behavior induced by chronic unpredictable stress (CUS) in mice. Moreover, we examined the effect of combined administration of ascorbic acid and ketamine on hippocampal phosphorylation of p70S6K and immunocontents of GLUA1 and PSD-95 in mice submitted to the CUS procedure. CUS procedure was applied for 21 days. Animals received a single coadministration of subeffective doses of ascorbic acid (0.1 mg/kg) and ketamine (0.1 mg/kg) and were subjected to behavioral evaluation 24 h after the treatments. Immediately after the behavioral observations the hippocampi were dissected for Western blotting analyses. Our results revealed that a single administration of subeffective doses of ascorbic acid and ketamine completely reversed the depressive-like behavior induced by CUS, however, this effect was not accompanied by changes in the phosphorylation of p70S6K and immunocontent of GLUA1 or PSD95 in the hippocampus. These findings point to a synergistic antidepressant-like effect of ascorbic acid and ketamine, paving the way for additional studies on the combined use of these compounds for the management of major depressive disorder (MDD). |
| Databáze: | OpenAIRE |
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