Inflammatory myofibroblastic tumor: A demographic, clinical and therapeutic study of 92 cases

Autor: Han Liang Jiang, Jian Zhong Gu, Nian Fang Yao, Guo Xiang Fu, Xu Feng Han, Chu Chu Xu
Rok vydání: 2019
Předmět:
End results
Adult
Male
medicine.medical_specialty
Adolescent
Patient demographics
medicine.medical_treatment
Seer database
02 engineering and technology
Disease
Neoplasms
Muscle Tissue
Young Adult
0502 economics and business
Epidemiology
0202 electrical engineering
electronic engineering
information engineering
medicine
Humans
Neoplasm Metastasis
Child
Aged
Proportional Hazards Models
Aged
80 and over
business.industry
Applied Mathematics
05 social sciences
Infant
Newborn
Soft tissue
Infant
General Medicine
Middle Aged
United States
Radiation therapy
Computational Mathematics
Treatment Outcome
Modeling and Simulation
Child
Preschool
Multivariate Analysis
020201 artificial intelligence & image processing
Histopathology
Female
Radiology
General Agricultural and Biological Sciences
business
050203 business & management
SEER Program
Zdroj: Mathematical biosciences and engineering : MBE. 16(6)
ISSN: 1551-0018
Popis: Purpose: Inflammatory myofibroblastic tumors (IMT) was a rare kind of tumor defined by WHO since 2012. Little was known about this disease. There were controversies about IMT's behavior, predilection site, age distribution, and the best treatment methods. Here we provided a systematic overview on tumor demographical, clinical, biological features as well as treatment efficacy based on real cases from Surveillance, Epidemiology, and End Results (SEER) database. Methods: 92 patients diagnosed with IMT by histopathology were drawn from SEER database between 2002 and 2014. Patient demographics, clinical features and treatment information were analyzed. Results: The mean age of onset was 47.4 ± 22.4 years (0 to 83y) and the ages prone to this disease are middle-aged (from 41y to 64y), accounting for 1/3 of all patients. Three peak ages of onsets were 0–4y, 36–40y and more than 50y. 42% of the tumors were located in the soft tissues of limbs, hip, shoulder, head, face and neck. The average tumor sizes were 6.5 ± 5.3cm (1cm to 25cm). Survival in the group of tumor size smaller than 6.5cm was better compared to group of tumor size larger than 6.5cm (P < 0.05). Most of the tumors were malignant or malignant potential (89%), though local and distant metastasis rate were low (5%). Surgery was the most common treatment. However, the survival benefit was still uncertain compared to adjuvant chemotherapy or radiotherapy. Multivariate regression analysis demonstrated that young patients had better survival than old ones. Conclusions: IMT was a malignant tumor with low risk of local and distant metastasis. The peak ages were 0-4y, 36-40y and more than 50y. The prone sites were the soft tissues of the limbs, hip, shoulder, head, face and neck. Tumor sizes and ages were the factors correlated with survival time.
Databáze: OpenAIRE
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