Nuclear receptors are the major targets of endocrine disrupting chemicals
| Autor: | Lucia Toporova, Patrick Balaguer |
|---|---|
| Přispěvatelé: | Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CCSD, Accord Elsevier |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty [SDV]Life Sciences [q-bio] Receptors Cytoplasmic and Nuclear Estrogen receptor 030209 endocrinology & metabolism Endocrine Disruptors Ligands Biochemistry 03 medical and health sciences Estrogen-related receptor 0302 clinical medicine Endocrinology Internal medicine Constitutive androstane receptor medicine Animals Humans Liver X receptor Receptor Molecular Biology Pregnane X receptor Chemistry 3. Good health [SDV] Life Sciences [q-bio] 030104 developmental biology Gene Expression Regulation Nuclear receptor 13. Climate action Environmental Pollutants Farnesoid X receptor |
| Zdroj: | Molecular and Cellular Endocrinology Molecular and Cellular Endocrinology, Elsevier, 2020, 502, pp.110665. ⟨10.1016/j.mce.2019.110665⟩ Molecular and Cellular Endocrinology, Elsevier, 2020, 502, pp.110665-. ⟨10.1016/j.mce.2019.110665⟩ |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2019.110665⟩ |
| Popis: | International audience; Endocrine disrupting chemicals (EDCs) are exogenous substances that are suspected to cause adverse effects in the endocrine system mainly by acting through their interaction with nuclear receptors such as the estrogen receptors α and β (ERα and ERβ), the androgen receptor (AR), the pregnan X receptor (PXR), the peroxisome proliferator activated receptors α and γ (PPARα, PPARγ) and the thyroid receptors α and β (TRα and TRβ). More recently, the retinoid X receptors (RXRα, RXRβ and RXRγ), the constitutive androstane receptor (CAR) and the estrogen related receptor γ (ERRγ) have also been identified as targets of EDCs. Finally, nuclear receptors still poorly studied for their interaction with environmental ligands such as the progesterone receptor (PR), the mineralocorticoid receptor (MR), the glucocorticoid receptor (GR), the retinoic acid receptors (RAR α, RARβ and RARγ), the farnesoid X receptor (FXR) and the liver X receptors α and β (LXRα and LXβ) as well are suspected targets of EDCs. Humans are generally exposed to low doses of pollutants, therefore the aim of current research is to identify the targets of EDCs at environmental concentrations. In this review, we analyze recent works referring that nuclear receptors are targets of EDCs and we highlight which EDCs are able to act at low concentrations. |
| Databáze: | OpenAIRE |
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