RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT
| Autor: | Song Han, Xiaohua He, Wanhong Liu, Biwen Peng, Qingqing Cheng, Yongjuan Liu, Xiong Chen, Fengfeng Zhang, Zhongchun Liu, Bingfei Zhou, Lanlan Dong |
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| Rok vydání: | 2015 |
| Předmět: |
Biophysics
Apoptosis Virus Replication Biochemistry Cell Line Enterovirus 71 Humans Phosphorylation Molecular Biology Protein kinase B Domain family Neurotropic virus biology Tumor Suppressor Proteins HEK 293 cells Cell Biology biology.organism_classification Virology Enterovirus A Human Cell biology Host-Pathogen Interactions Akt phosphorylation Signal transduction Hand Foot and Mouth Disease Proto-Oncogene Proteins c-akt |
| Zdroj: | Biochemical and Biophysical Research Communications. 458:810-815 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2015.02.035 |
| Popis: | Enterovirus 71 (EV71) is a neurotropic virus that causes hand, foot and mouth disease (HFMD), occasionally leading to death. As a member of the RAS association domain family (RASSFs), RASSF4 plays important roles in cell death, tumor development and signal transduction. However, little is known about the relationship between RASSF4 and EV71. Our study reveals for the first time that RASSF4 promotes EV71 replication and then accelerates AKT phosphorylation inhibition in EV71-infected 293T cells, suggesting that RASSF4 may be a potential new target for designing therapeutic measures to prevent and control EV71 infection. |
| Databáze: | OpenAIRE |
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