Precipitation complexation method produces cannabidiol/beta-cyclodextrin inclusion complex suitable for sublingual administration of cannabidiol
| Autor: | Pekka Jarho, Tomi Järvinen, Kristiina Järvinen, Janne Mannila |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Drug Compounding Administration Sublingual Pharmaceutical Science Administration Oral Biological Availability Absorption (skin) Pharmacology digestive system Inclusion compound Sublingual administration Absorption Sublingual Absorption chemistry.chemical_compound Pharmacokinetics Oral administration medicine Animals Cannabidiol Chemical Precipitation Ethanol beta-Cyclodextrins Buccal administration digestive system diseases surgical procedures operative chemistry Solubility Female Rabbits medicine.drug Nuclear chemistry |
| Zdroj: | Journal of pharmaceutical sciences. 96(2) |
| ISSN: | 0022-3549 |
| Popis: | In the present study, the precipitation complexation method was used to prepare a complex of cannabidiol (CBD) with beta-CD. The effect of beta-CD-complexation on the sublingual absorption of CBD was studied in rabbits. A solid CBD/beta-CD inclusion complex was prepared by precipitation and the effect of complex formation on the dissolution rate of CBD was studied. The absorption of CBD (a 250 microg/kg dose of CBD in all formulations) after sublingual administration of solid CBD/beta-CD complex and ethanolic CBD solution, and after oral administration of ethanolic CBD solution, was studied in vivo in rabbits. The dissolution rate of solid CBD/beta-CD complex in vitro was significantly (p0.05) higher than that of plain CBD. The absorption of CBD (AUC0-300 min) decreased in the following order: sublingual ethanolic CBD solution (420+/-120 ngxmin/mL; mean+/-SD; n=4)sublingual solid CBD/beta-CD complex (270+/-120 ngxmin/mL)oral ethanolic CBD solution (concentrations in plasma below the quantitation limit). The results demonstrate that sublingual administration of a solid CBD/beta-CD complex enhances the absorption of CBD in rabbits when compared to oral administration of ethanolic CBD. Furthermore, the solid CBD/beta-CD complex may provide an alternative formulation for sublingual administration of CBD. |
| Databáze: | OpenAIRE |
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