Suspected non-AD pathology in mild cognitive impairment
| Autor: | Sanjeev N. Vaishnavi, Christos Davatzikos, Sandhitsu R. Das, Paul A. Yushkevich, Bradford C. Dickerson, Nirali Butala, David A. Wolk, Laura E.M. Wisse |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Aging Pathology medicine.medical_specialty Hippocampus Neuroimaging Disease Article Cognition Alzheimer Disease Memory mental disorders medicine Humans Cognitive Dysfunction cardiovascular diseases Aged Aged 80 and over Amyloid beta-Peptides General Neuroscience Amyloidosis Neurodegeneration Snap Middle Aged medicine.disease Peptide Fragments Nerve Degeneration Female Neurology (clinical) Geriatrics and Gerontology Alzheimer's disease Psychology Developmental Biology |
| Zdroj: | Neurobiology of Aging. 36:3152-3162 |
| ISSN: | 0197-4580 |
| Popis: | We aim to better characterize mild cognitive impairment (MCI) patients with suspected non-Alzheimer's disease (AD) pathology (SNAP) based on their longitudinal outcome, cognition, biofluid, and neuroimaging profile. MCI participants (n = 361) from ADNI-GO/2 were designated "amyloid positive" with abnormal amyloid-beta 42 levels (AMY+) and "neurodegeneration positive" (NEU+) with abnormal hippocampal volume or hypometabolism using fluorodeoxyglucose-positron emission tomography. SNAP was compared with the other MCI groups and with AMY- controls. AMY-NEU+/SNAP, 16.6%, were older than the NEU- groups but not AMY- controls. They had a lower conversion rate to AD after 24 months than AMY+NEU+ MCI participants. SNAP-MCI participants had similar amyloid-beta 42 levels, florbetapir and tau levels, but larger white matter hyperintensity volumes than AMY- controls and AMY-NEU- MCI participants. SNAP participants performed worse on all memory domains and on other cognitive domains, than AMY-NEU- participants but less so than AMY+NEU+ participants. Subthreshold levels of cerebral amyloidosis are unlikely to play a role in SNAP-MCI, but pathologies involving the hippocampus and cerebrovascular disease may underlie the neurodegeneration and cognitive impairment in this group. |
| Databáze: | OpenAIRE |
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