Vascular Abnormalities within Normal Appearing Tissue in Chronic Traumatic Brain Injury
| Autor: | Danielle K. Sandsmark, Carol Moore, John A. Butman, Erika Silverman, Kimbra Kenney, Jamie E Podell, Ramon Diaz-Arrastia, Hanzhang Lu, Dzung L. Pham, Franck Amyot, Tawny Meredith-Duliba, Yi Yu Chou, Margalit Haber |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Traumatic brain injury Neuroimaging Fluid-attenuated inversion recovery 030218 nuclear medicine & medical imaging 03 medical and health sciences Vascular reactivity 0302 clinical medicine Brain Injuries Traumatic Brain Injury Chronic medicine Humans Encephalomalacia medicine.diagnostic_test business.industry Magnetic resonance imaging Original Articles medicine.disease Magnetic Resonance Imaging Cerebral blood flow Cerebrovascular Circulation Female Neurology (clinical) business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Journal of Neurotrauma. 35:2250-2258 |
| ISSN: | 1557-9042 0897-7151 |
| Popis: | Magnetic resonance imaging (MRI) is a powerful tool for visualizing traumatic brain injury(TBI)-related lesions. Trauma-induced encephalomalacia is frequently identified by its hyperintense appearance on fluid-attenuated inversion recovery (FLAIR) sequences. In addition to parenchymal lesions, TBI commonly results in cerebral microvascular injury, but its anatomical relationship to parenchymal encephalomalacia is not well characterized. The current study utilized a multi-modal MRI protocol to assess microstructural tissue integrity (by mean diffusivity [MD] and fractional aniosotropy [FA]) and altered vascular function (by cerebral blood flow [CBF] and cerebral vascular reactivity [CVR]) within regions of visible encephalomalacia and normal appearing tissue in 27 chronic TBI (minimum 6 months post-injury) subjects. Fifteen subjects had visible encephalomalacias whereas 12 did not have evident lesions on MRI. Imaging from 14 age-matched healthy volunteers were used as controls. CBF was assessed by arterial spin labeling (ASL) and CVR by measuring the change in blood-oxygen-level–dependent (BOLD) MRI during a hypercapnia challenge. There was a significant reduction in FA, CBF, and CVR with a complementary increase in MD within regions of FLAIR-visible encephalomalacia (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|