A Single-Parameter Model of the Immune Response to Bacterial Invasion
| Autor: | Lester Caudill |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Process (engineering)
General Mathematics Immunology Computational biology Biology General Biochemistry Genetics and Molecular Biology Immune system Drug Resistance Bacterial Humans Set (psychology) General Environmental Science Pharmacology Bacteria Mathematical model business.industry General Neuroscience Models Immunological Computational Biology Single parameter Bacterial Infections Mathematical Concepts Computational Theory and Mathematics Host-Pathogen Interactions Artificial intelligence Immunocompetence General Agricultural and Biological Sciences business |
| Zdroj: | Bulletin of Mathematical Biology. 75:1434-1449 |
| ISSN: | 1522-9602 0092-8240 |
| DOI: | 10.1007/s11538-013-9854-1 |
| Popis: | The human immune response to bacterial pathogens is a remarkably complex process, involving many different cell types, chemical signals, and extensive lines of communication. Mathematical models of this system have become increasingly high-dimensional and complicated, as researchers seek to capture many of the major dynamics. In this paper, we argue that, in some important instances, preference should be given to low-dimensional models of immune response, as opposed to their high-dimensional counterparts. One such model is analyzed and shown to reflect many of the key phenomenological properties of the immune response in humans. Notably, this model includes a single parameter that, when combined with a single set of reference parameter values, may be used to quantify the overall immunocompetence of individual hosts. |
| Databáze: | OpenAIRE |
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