Baboon and cotton-top tamarin B2m cDNA sequences and the evolution of primate β2-microglobulin
| Autor: | Carolyn Doyle, Robert E. Ruiz, Frances E. Ward, Bruce Lee Hall |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Primates
Molecular Sequence Data Immunology Rodentia Polymerase Chain Reaction Homology (biology) Cell Line Negative selection Molecular evolution biology.animal Animals Immunology and Allergy Primate Amino Acid Sequence Phylogeny Papio hamadryas Genetics Base Sequence biology Tamarin General Medicine biology.organism_classification Saguinus oedipus Saguinus beta 2-Microglobulin Papio Baboon |
| Zdroj: | Human Immunology. 39:188-194 |
| ISSN: | 0198-8859 |
| Popis: | Nonhuman primates represent phylogenetic intermediates for studying the divergence of human and murine β 2 Ms. We report the nucleotide sequences of B 2 m cDNA clones from a baboon cell line, 26CB-1 ( Papio hamadryas ); primates: Cercopithecoida), and a cotton-top tamarin cell line, 1605L ( Saguinus oedipus ; primates: Ceboidea). The baboon and tamarin B 2 m sequences indicate a very slow rate of B 2 m evolution in primates relative to that in murid rodents. Phenotypic evolution of β 2 M has also been very conservative in primates, with only 9–14 substitutions separating baboon or tamarin β 2 Ms from those of humans or orangutans. Analyses of silent and amino-acid-altering nucleotide substitutions provide evidence that negative selection has acted to limit variability in β strands of primate β 2 Ms, while positive selection has promoted diversity in non-β-strand regions of murine β 2 Ms. No evidence for the action of selection upon β 2 M residues that contact the class I heavy chain was found in primates or mice. The finding that different selective forces have operated upon primate and murine β 2 Ms suggests that β 2 M may have evolved to serve distinct functions in primates and mice. |
| Databáze: | OpenAIRE |
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