Lack of association of human leukocyte antigen-B7 with COPD and rate of decline in lung function
| Autor: | Ikuma Kasuga, Jian Ruan, John E. Connett, Andrew J. Sandford, Nicholas R. Anthonisen |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Time Factors Genotype Human leukocyte antigen 030204 cardiovascular system & hematology White People HLA-B7 Antigen Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Gene Frequency Forced Expiratory Volume Prevalence medicine Humans COPD Allele 030223 otorhinolaryngology Lung Genotyping Allele frequency Aged Chi-Square Distribution business.industry Smoking Case-control study Middle Aged medicine.disease Lung function Respiratory Function Tests respiratory tract diseases 3. Good health HLA medicine.anatomical_structure Glutathione S-Transferase pi Case-Control Studies Immunology Female business Chi-squared distribution Heme Oxygenase-1 |
| Zdroj: | Respiratory Medicine. 99:1528-1533 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2005.03.021 |
| Popis: | Summary Background : Although variation in the human leukocyte antigen ( HLA ) locus is associated with various diseases, there have been a limited number of studies that have examined the possible role of HLA in chronic obstructive pulmonary disease (COPD). Only HLA-B7 has been shown to be correlated with low forced expiratory volume in 1s (FEV 1 ) in Caucasians; however, this finding has not been replicated. The aim of this study was to investigate the contribution of the HLA-B7 allele to COPD and to rate of decline of lung function. Methods : We determined the prevalence of HLA-B7 in a group of COPD patients and a non-obstructed control group of smokers by using a polymerase chain reaction-based genotyping assay. We also determined the prevalence of HLA-B7 in smokers selected from the National Heart Lung and Blood Institute, Lung Health Study for having the fastest and slowest decline of lung function. Results : No significant difference was found in the frequency of HLA-B7 between the COPD and non-obstructed groups. There was also no significant association of HLA-B7 with rate of decline of lung function. Conclusion : These data indicate that HLA-B7 does not contribute to COPD or rate of decline of FEV 1 in smokers. |
| Databáze: | OpenAIRE |
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