High prevalence of hepatitis C virus infection in patients with B-cell lymphoproliferative disorders in Italy
| Autor: | Bruno Rotoli, Federico Chiurazzi, Marco Picardi, Margherita Matarazzo, Aurora Apuzzo, Maria Luisa Gobbo, Rosario Notaro, Salvatore Garofalo, Gennaro De Rosa, Maria Grimaldi, Amalia De Renzo |
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| Přispěvatelé: | De Rosa, G, Gobbo, Ml, De Renzo, A, Notaro, R, Garofalo, S, Grimaldi, M, Apuzzo, A, Chiurazzi, F, Picardi, Marco, Matarazzo, M, Rotoli, B. |
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Hepatitis C virus Chronic lymphocytic leukemia Lymphoproliferative disorders Hepacivirus medicine.disease_cause Gastroenterology Liver disease hemic and lymphatic diseases Internal medicine medicine Humans Multiple myeloma Aged B-Lymphocytes business.industry Lymphoma Non-Hodgkin Age Factors Macroglobulinemia Hematology Middle Aged medicine.disease Hepatitis B Hepatitis C Lymphoproliferative Disorders Lymphoma Italy Immunology RNA Viral Female Viral disease business |
| Popis: | Starting from the observation that a number of consecutive patients with non-Hodgkin's lymphoma (NHL) resulted positive for hepatitis C virus (HCV) antibodies on routine testing, we set up a survey for HCV contact prevalence in all patients with lymphoproliferative disorders (LPD) followed in our institution. We searched for HCV antibodies by a third-generation ELISA technique, followed by a confirmation test (RIBA III); serum viral RNA and HCV genotype were investigated by a RT-PCR technique. We screened a total of 315 patients suffering from B-NHL (91), multiple myeloma (56), MGUS (48), chronic lymphocytic leukemia (57), Waldentrom's macroglobulinemia (13), Hodgkin's disease (HD)(43), and T-NHL (9). While only 1 of 52 patients with a non-B-LPD (HD or T-NHL) had signs of HCV contact (i.e., 1.9%, which is in the range of the normal population in the South of Italy), 59 of 263 patients with a B-LPD (22.4%) had HCV antibodies or RNA, or both, with no major differences among the various types of disorders, except for WM, in which the rate was higher (61.5%). The same prevalence was found for patients tested at diagnosis or during the follow-up, and in transfused or never-transfused patients. Only a few patients were aware of having a liver disease; one-half of HCV-positive patients never had transaminase increase. A review of data from Central and Northern Italy is included, showing similar findings; a report from Japan has confirmed such an association, while limited surveys in England have not revealed any correlation. These findings may have important biological and clinical implications. |
| Databáze: | OpenAIRE |
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