Ursodeoxycholic Acid May Inhibit Environmental Aging-Associated Hyperpigmentation
| Autor: | Su Yeon Kim, Hak Tae Kim, Ik Jun Moon, Youngsup Song, Seung Hwan Paik, Sung Eun Chang, Hanju Yoo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
antioxidant photoaging Physiology Photoaging Clinical Biochemistry ultraviolet light Human skin Pharmacology Matrix metalloproteinase Biochemistry Article Proinflammatory cytokine Melanin 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine fibroblasts medicine Ultraviolet light Molecular Biology particulate matter integumentary system Chemistry lcsh:RM1-950 environmental aging Cell Biology medicine.disease Hyperpigmentation Ursodeoxycholic acid ursodeoxycholic acid 030104 developmental biology lcsh:Therapeutics. Pharmacology hyperpigmentation medicine.symptom medicine.drug |
| Zdroj: | Antioxidants, Vol 10, Iss 267, p 267 (2021) Antioxidants Volume 10 Issue 2 |
| ISSN: | 2076-3921 |
| Popis: | Extrinsic aging of the skin caused by ultraviolet (UV) light or particulate matter is often manifested by hyperpigmentation due to increased melanogenesis in senescent skin. Ursodeoxycholic acid (UDCA), which has been commonly used as a health remedy for liver diseases, is known to possess antioxidant properties. This study was done to investigate whether UDCA inhibits cellular aging processes in the cells constituting human skin and it reduces melanin synthesis. ROS, intracellular signals, IL-1α, IL-8, TNF-α, cyclooxygenase (COX)-2, type I collagen, and matrix metalloproteinases (MMPs) levels were measured in human dermal fibroblasts treated with or without UDCA after UV exposure. Melanin levels and mechanistic pathways for melanogenesis were investigated. UDCA decreased ROS, senescence-associated secretory phenotype (SASP), and proinflammatory cytokines induced by UV treatment. UDCA reduced melanogenesis in normal human melanocytes cocultured with skin constituent cells. Our results suggest that UDCA could be a comprehensive agent for the treatment of environmental aging-associated hyperpigmentation disorders. |
| Databáze: | OpenAIRE |
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