An avian B-lymphocyte protein associated with β2-microglobulin
| Autor: | Max D. Cooper, Chen-lo H. Chen, James M. Pickel |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
animal structures
Glycosylation Macromolecular Substances Immunoprecipitation medicine.drug_class Lymphocyte Immunology Biology Immunofluorescence Monoclonal antibody Major Histocompatibility Complex chemistry.chemical_compound Bursa of Fabricius Antigen Genetics medicine Animals Isoelectric Point Glycoproteins chemistry.chemical_classification B-Lymphocytes medicine.diagnostic_test Beta-2 microglobulin Histocompatibility Antigens Class I Antibodies Monoclonal Precipitin Tests Molecular biology Molecular Weight medicine.anatomical_structure chemistry Antigens Surface beta 2-Microglobulin Glycoprotein Chickens |
| Zdroj: | Immunogenetics. 32:1-7 |
| ISSN: | 1432-1211 0093-7711 |
| Popis: | A member of the family of β2-microglobulin (β2m)-associated cell surface glycoproteins was identified by the CB3 monoclonal antibody. The Mr 50 000 heavy chain of the CB3 antigen differs from conventional class I heavy chains (Mr 45 000) in the extent of glycosylation, charge, and peptide composition. Because of its selective expression on avian B cells and its similarity to mammalian class I-like molecules, we speculate that the CB3 antigen may play a role in T- and B-cell interactions. rommental stimuli is to prepare monoclonal antibodies against bursal cell surface antigens. Using this strategy we have identified several proteins that are expressed on the surface of bursal B cells (Chen and Cooper 1987). In the present study we characterize CB3, a class I-like molecule associated with β2-microglobulin (β2m) on the surface of both bursal and peripheral B cells. |
| Databáze: | OpenAIRE |
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