Solid-phase synthesis of biocompatible N-heterocyclic carbene-Pd catalysts using a sub-monomer approach
| Autor: | Paul T. Cowling, Durgadas Cherukaraveedu, Annamaria Lilienkampf, Gavin P. Birch, Mark Bradley |
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| Rok vydání: | 2019 |
| Předmět: |
Fluorophore
Cell Survival Biocompatible Materials 010402 general chemistry Ligands 01 natural sciences Biochemistry Catalysis chemistry.chemical_compound 3D cell culture Solid-phase synthesis Heterocyclic Compounds Humans Physical and Theoretical Chemistry Solid-Phase Synthesis Techniques Bioconjugation Molecular Structure 010405 organic chemistry Organic Chemistry Prodrug Combinatorial chemistry 0104 chemical sciences Monomer chemistry MCF-7 Cells Carbene Methane Palladium |
| Zdroj: | Cherukaraveedu, D, Cowling, P, Birch, G, Bradley, M & Lilienkampf, A 2019, ' Solid-Phase Synthesis of Biocompatible N-Heterocyclic Carbene–Pd Catalysts Using a Sub-monomer Approach ', Organic & Biomolecular chemistry . https://doi.org/10.1039/C9OB00716D |
| ISSN: | 1477-0539 |
| DOI: | 10.1039/C9OB00716D |
| Popis: | Taking inspiration from the assembly of so-called peptoids (N-alkylglycine oligomers) we present a new synthetic methodology whereby N-heterocyclic carbene (NHC) based Pd ligands were assembled using a sub-monomer approach and loaded with Pd via solid-phase synthesis. This allowed the rapid generation a library of NHC–palladium catalysts that were readily functionalised to allow bioconjugation. These catalysts were able to rapidly activate a caged fluorophore and ‘switch-on’ an anticancer prodrug in 3D cell culture. |
| Databáze: | OpenAIRE |
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