Pathologic effects in rodents exposed to sodium combustion products
| Autor: | R.H. Busch, T.M. Graham, J.K. Briant, K.E. McDonald, J.E. Morris |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Larynx Pathology medicine.medical_specialty Hot Temperature Sodium Guinea Pigs Carbonates chemistry.chemical_element Epiglottis Biochemistry Mice Species Specificity Edema otorhinolaryngologic diseases medicine Animals Respiratory system General Environmental Science Respiratory distress Respiration Stomach Pharynx Rats Inbred Strains Anatomy respiratory system Mucus Rats medicine.anatomical_structure chemistry Toxicity medicine.symptom |
| Zdroj: | Environmental Research. 31:138-147 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/0013-9351(83)90070-1 |
| Popis: | Three species of rodents exhibited respiratory distress when exposed to aerosols of sodium combustion products, the major constituent of which was shown to be sodium carbonate. At the higher doses, animals died during or shortly after 2 hr exposures. Lesions, primarily involving the pharynx and larynx, included accumulation of mucus, vesiculation, and mucosal edema. Other lesions included edema and vesiculation of the anterior trachea, hemorrhage in the lungs, and severe gastric tympany. Basal epithelial cells of the posterior pharynx and anterior trachea had enlarged mitochondria following exposures of 1 hr or more. |
| Databáze: | OpenAIRE |
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