Pharmacokinetics and Safety Studies in Rodent Models Support Development of EPICERTIN as a Novel Topical Wound-Healing Biologic for Ulcerative Colitis

Autor:	Daniel Tusé, Micaela Reeves, Joshua Royal, Krystal T. Hamorsky, Hanna Ng, Maria Arolfo, Carol Green, Abhishek Trigunaite, Toufan Parman, Goo Lee, Nobuyuki Matoba
Rok vydání:	2022
Předmět:	Male Pharmacology Biological Products Wound Healing Administration Topical Rodentia Rats Mice Inbred C57BL Rats Sprague-Dawley Disease Models Animal Mice Animals Molecular Medicine Colitis Ulcerative Female
Zdroj:	Journal of Pharmacology and Experimental Therapeutics. 380:162-170
ISSN:	1521-0103 0022-3565
Popis:	The novel wound-healing biologic EPICERTIN, a recombinant analog of cholera toxin B subunit, is in early development for the management of ulcerative colitis. This study established for the first time the pharmacokinetics (PK), bioavailability (BA), and acute safety of EPICERTIN in healthy and dextran sodium sulfate-induced colitic mice and healthy rats. For PK and BA assessments, single administrations of various concentrations of EPICERTIN were given intravenously or intrarectally to healthy and colitic C57BL/6 mice and to healthy Sprague-Dawley rats. After intravenous administration to healthy animals, the drug's plasma half-life (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2325760699d38df82660b89afa3917b1 https://doi.org/10.1124/jpet.121.000904 Zobrazit plný text záznamu