Epinephrine and clonidine do not improve intrathecal sufentanil analgesia after total hip replacement†
| Autor: | Zdravko Gamulin, A. Weber, E. Van Gessel, Roxane Fournier |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine Sufentanil Visual analogue scale Arthroplasty Replacement Hip Analgesic Blood Pressure Clonidine Diclofenac Double-Blind Method Heart Rate medicine Humans Aged Pain Measurement Aged 80 and over Analgesics Pain Postoperative business.industry Surgery Analgesics Opioid Anesthesiology and Pain Medicine Anesthesia Morphine Drug Therapy Combination Female medicine.symptom business Postoperative nausea and vomiting medicine.drug |
| Popis: | Background. We compared analgesia after intrathecal sufentanil alone, sufentanil with epinephrine 200µg and sufentanil with clonidine 30 µg in patients after total hip replacement, the endpoints being onset and duration of action. Methods. We performed a randomized double‐blind study of 45 patients for elective total hip arthroplasty using continuous spinal anaesthesia. As soon as a pain score higher than 3 on a 10 cm visual analogue scale was reported, sufentanil 7.5 µg alone, sufentanil 7.5 µg + epinephrine 200 µg or sufentanil 7.5 µg + clonidine 30 µg in 2 ml normal saline was given intrathecally. Pain scores, rescue analgesia (diclofenac and morphine) and adverse effects (respiratory depression, postoperative nausea and vomiting, itching) were observed for 24h after surgery. Results. Time to a pain score of 3 [281 (36) vs 288 (23) vs 305 (30) min] were similar in all three groups. Adverse effects and analgesic requirements during the first 24h were also similar. Conclusion. After total hip replacement, all three analgesic regimens gave good analgesia with comparable onset and duration of action, and minor adverse effects. Br J Anaesth 2002; 89: 562-6 |
| Databáze: | OpenAIRE |
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