Effects of central airway shunting on the mechanical impedance of the mouse lung
| Autor: | John Thompson-Figueroa, Lennart K. A. Lundblad, Minara Aliyeva, Benjamin L. Schwartz, Jason H. T. Bates, Gilman B. Allen, Ron C. Anafi |
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| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Lung business.industry Airway Resistance Biomedical Engineering Mechanical impedance Respiratory physiology Input impedance respiratory system Models Biological respiratory tract diseases Shunting Mice Airway resistance medicine.anatomical_structure Elastic Modulus medicine Respiratory Mechanics Animals Computer Simulation Compartment (pharmacokinetics) Airway business |
| Zdroj: | Annals of biomedical engineering. 39(1) |
| ISSN: | 1573-9686 |
| Popis: | The mechanical properties of the lung are embodied in its mechanical input impedance, which it is interpreted in physiological terms by being fit with a mathematical model. The normal lung is extremely well described by a model consisting of a single uniformly ventilated compartment comprised of tissue having a constant-phase impedance, but to describe the abnormal lung it frequently becomes necessary to invoke additional compartments. To date, all evidence of regional mechanical heterogeneity in the mouse lung has been assumed to be of the parallel variety. We therefore investigated the use of a serial heterogeneity model, relative to parallel heterogeneity and homogeneous models, for describing impedance spectra in mice subjected to a variety of interventions designed to make their lungs heterogeneous. We found that functional evidence of the finite stiffness of the airway wall in mice with airways obstruction can sometimes be apparent in lung impedance below 20 Hz. The model estimates of airway stiffness were smaller than direct estimates obtained from micro-CT images of the lung in vivo, suggesting that the conducting airways alone are likely not the precise anatomical correlate of proximal functional stiffness in the lung. Nevertheless, we conclude that central airway shunting in mice can sometimes be an important physiological phenomenon. |
| Databáze: | OpenAIRE |
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