Circadian rhythm in Alzheimer disease after trazodone use
| Autor: | Luciana L. Louzada, Otávio de Toledo Nóbrega, Talyta Cortez Grippe, Bruno S B Gonçalves, Juliana Lima Quintas, Einstein Francisco Camargos, Janeth de Oliveira Silva Naves |
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| Rok vydání: | 2015 |
| Předmět: |
Activity Cycles
Male Time Factors Physiology Circadian clock Context (language use) Dark therapy Alzheimer Disease Sleep Disorders Circadian Rhythm Physiology (medical) medicine Humans Circadian rhythm Cognitive decline Aged Aged 80 and over Chronobiology business.industry Trazodone Actigraphy Treatment Outcome Female Sleep business Neuroscience medicine.drug |
| Zdroj: | Chronobiology International. 32:1311-1314 |
| ISSN: | 1525-6073 0742-0528 |
| Popis: | A circadian rhythm is a cycle of approximately 24 h, responsible for many physiological adjustments, and ageing of the circadian clock contributes to cognitive decline. Rhythmicity is severely impaired in Alzheimer disease (AD) and few therapeutic attempts succeeded in improving sleep disorders in such context. This study evaluated sleep parameters by actigraphy in 30 AD patients before and after trazodone use for 2 weeks, and we show a significant improvement in relative rhythm amplitude (RRA), compatible with a more stable daytime behavioral pattern. So, trazodone appears to produce a stabilization of the circadian rhythms in individuals with AD. |
| Databáze: | OpenAIRE |
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