MRI of autosomal dominant pure spastic paraplegia
| Autor: | M Herning, Jørgen E. Nielsen, E Fallentin, K. Krabbe, K Fenger |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Hereditary spastic paraplegia Chromosome Disorders Corpus callosum Corpus Callosum Diagnosis Differential Central nervous system disease medicine Spastic Humans Radiology Nuclear Medicine and imaging Genes Dominant Chromosome Aberrations Pyramidal tracts medicine.diagnostic_test Spastic Paraplegia Hereditary business.industry Brain Magnetic resonance imaging Middle Aged medicine.disease Spinal cord Magnetic Resonance Imaging medicine.anatomical_structure Spinal Cord Female Neurology (clinical) Cardiology and Cardiovascular Medicine business Paraplegia |
| Zdroj: | Neuroradiology. 39:724-727 |
| ISSN: | 1432-1920 0028-3940 |
| DOI: | 10.1007/s002340050495 |
| Popis: | We examined 16 patients with autosomal dominant pure spastic paraplegia (HSP) and 15 normal controls matched for age and sex using MRI of the brain and spinal cord. Images were assessed qualitatively by two independent radiologists, blinded to the clinical diagnosis. Areas of the brain and corpus callosum on one midsagittal slice and the area of the brain on one axial slice were measured and a "corpus-callosum index" expressing the size of the corpus callosum relative to that of the brain was calculated. Cross-sectional areas and anteroposterior and transverse diameters of the spinal cord at the levels of C 2, C 5, T 3, T 6, T 9 and T 11 were measured. No significant differences between patients and controls were found on qualitative evaluation of the images. The patients had a significantly smaller corpus callosum and "corpus-callosum index" than controls. This finding, not reported previously, might indicate that the disease process in pure HSP is not confined to the spinal cord. The anteroposterior diameters of the spinal cord at T 3 and T 9 were significantly smaller in patients than in controls. This might correspond to the degeneration of the pyramidal tracts and the dorsal columns described at neuropathological examination. |
| Databáze: | OpenAIRE |
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