Methamphetamine self-administration in a runway model of drug-seeking behavior in male rats

Autor: Aaron Ettenberg, Mona Akhiary, Erin M. Purvis, Adam K. Klein
Rok vydání: 2018
Předmět:
Male
Clinical Biochemistry
Self Administration
Pharmacology
Toxicology
Biochemistry
Methamphetamine
Rats
Sprague-Dawley
Substance Misuse
Behavioral Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Medicine
Reinforcement
Infusions
Intravenous
media_common
Psychomotor learning
Behavior
Animal
Pharmacology and Pharmaceutical Sciences
Animal studies
Intravenous
Self-administration
Locomotion
medicine.drug
Drug
Infusions
Runway
media_common.quotation_subject
Drug-Seeking Behavior
Operant behavior
Basic Behavioral and Social Science
Article
03 medical and health sciences
Reward
Behavioral and Social Science
Animals
Drug self-administration
Biological Psychiatry
Behavior
Neurology & Neurosurgery
Animal
business.industry
Meth
030227 psychiatry
Rats
Good Health and Well Being
Anxiogenic
chemistry
Sprague-Dawley
Drug Abuse (NIDA only)
business
030217 neurology & neurosurgery
Zdroj: Pharmacology, biochemistry, and behavior. 175
ISSN: 1873-5177
Popis: Cocaine administration has been shown to produce immediate positive (rewarding) and subsequent negative (anxiogenic) effects in humans and animals. These dual and opposing affective responses have been more difficult to demonstrate with administration of methamphetamine (meth). While animal studies have reliably demonstrated the positive reinforcing effects of the drug, reports of negative aftereffects following acute exposure have been few in number and contradictory in nature. The current research was devised to assess the effects of acute meth using a runway model of self-administration that is uniquely sensitive to both the positive and negative effects of a drug reinforcer in the same animal on the same trial. Male rats were allowed to traverse a straight alley once a day for 16 consecutive days/trials where entry into the goal box resulted in a single IV injection of meth (0.25, 0.5 or 1.0 mg/kg/inj.). The chosen doses were confirmed to be psychoactive as they produced dose-dependent increases in motoric/locomotor activation in these same subjects. The results demonstrated a U-shaped dose-response curve for the reinforcing effects of meth in that the intermediate dose group (0.5 mg/kg) produced the strongest approach behavior in the runway. Unlike other psychomotor stimulants, like cocaine, animals running for IV meth exhibited no evidence of any significant approach-avoidance behaviors reflective of the drug's negative anxiogenic effects. These results suggest that the abuse potential for meth is likely higher than for other shorter-acting psychomotor stimulants and reaffirms the utility of the runway procedure as a screen for a substance's abuse potential.
Databáze: OpenAIRE
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