Changes in Liver Congestion in Patients with Budd–Chiari Syndrome following Endovascular Interventions: Assessment with Transient Elastography
| Autor: | Sasidharan Rajesh, Shiv Kumar Sarin, Saloni N. Desai, Amar Mukund, Sudheer S. Pargewar |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Adolescent Wilcoxon signed-rank test medicine.medical_treatment Budd-Chiari Syndrome Inferior vena cava 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fibrosis medicine Humans Radiology Nuclear Medicine and imaging Child business.industry Endovascular Procedures Middle Aged medicine.disease Treatment Outcome medicine.vein Budd–Chiari syndrome Mann–Whitney U test Elasticity Imaging Techniques Female 030211 gastroenterology & hepatology Radiology Cardiology and Cardiovascular Medicine Hepatic fibrosis business Transient elastography Transjugular intrahepatic portosystemic shunt |
| Zdroj: | Journal of Vascular and Interventional Radiology. 28:683-687 |
| ISSN: | 1051-0443 |
| Popis: | Purpose Transient elastography (TE) is routinely used for noninvasive staging of hepatic fibrosis. The objective of the present study was to investigate the role of TE (FibroScan) in determining changes in liver congestion in patients with Budd–Chiari syndrome (BCS) treated by endovascular interventions and determine the effects of pretreatment Meta-analysis of Histological Data in Viral Hepatitis (METAVIR) fibrosis score on posttreatment liver stiffness (LS). Materials and Methods Twenty-five patients undergoing endovascular procedures for treatment of BCS underwent TE immediately before and within 24 hours after the procedure. Fifteen patients available for 3-month follow-up were again subjected to TE. Mean LS values before and after intervention were compared in 12 of these patients for whom METAVIR scores were available. Pressure gradient changes across the stenosed hepatic veins/inferior vena cava were measured during the procedure. Statistical analysis of these data was performed by Wilcoxon signed-rank test, Mann–Whitney U test, and Pearson product–moment correlation coefficient. Results Significant differences were found between mean LS measurements before and within 24 hours after intervention ( Z -score = 4.372) and between the mean values obtained before and 3 months after treatment ( Z -score = 3.408). Mean changes in LS values after intervention in patients with METAVIR fibrosis scores ≤ 2 and > 2 were not significant. There was no correlation between changes in pressure gradients and the degree of LS. Conclusions TE is a useful tool to assess the reduction in hepatic congestion in patients with BCS undergoing endovascular interventions. |
| Databáze: | OpenAIRE |
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