Chronic Carcinogenicity Study of Gasoline Vapor Condensate (GVC) and GVC Containing Methyl Tertiary-Butyl Ether in F344 Rats
| Autor: | Thomas H. March, Edward B. Barr, Charles R. Clark, Brad M. Tibbetts, Betty J. Skipper, Janet M. Benson, Andrew P. Gigliotti, Lorraine Twerdok |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Methyl Ethers medicine.medical_specialty Pathology Carcinogenicity Tests Health Toxicology and Mutagenesis Physiology Mucous membrane of nose Kidney Toxicology Sex Factors medicine Animals Respiratory system Carcinogen Air Pollutants Dose-Response Relationship Drug Inhalation Chemistry Body Weight Original Articles Organ Size Rats Inbred F344 Rats Nasal Mucosa Dose–response relationship medicine.anatomical_structure Toxicity Carcinogens Female Histopathology Volatilization Gasoline |
| Zdroj: | Journal of Toxicology and Environmental Health. Part a |
| ISSN: | 1087-2620 1528-7394 |
| Popis: | Chronic inhalation studies were conducted to compare the toxicity and potential carcinogenicity of evaporative emissions from unleaded gasoline (GVC) and gasoline containing the oxygenate methyl tertiary-butyl ether (MTBE; GMVC). The test materials were manufactured to mimic vapors people would be exposed to during refueling at gas stations. Fifty F344 rats per gender per exposure level per test article were exposed 6 h/d, 5 d/wk for 104 wk in whole body chambers. Target total vapor concentrations were 0, 2, 10, or 20 g/m³ for the control, low-, mid-, and high-level exposures, respectively. Endpoints included survival, body weights, clinical observations, organs weights, and histopathology. GVC and GMVC exerted no marked effects on survival or clinical observations and few effects on organ weights. Terminal body weights were reduced in all mid- and high-level GVC groups and high-level GMVC groups. The major proliferative lesions attributable to gasoline exposure with or without MTBE were renal tubule adenomas and carcinomas in male rats. GMV exposure led to elevated testicular mesothelioma incidence and an increased trend for thyroid carcinomas in males. GVMC inhalation caused an increased trend for testicular tumors with exposure concentration. Mid- and high-level exposures of GVC and GMVC led to elevated incidences of nasal respiratory epithelial degeneration. Overall, in these chronic studies conducted under identical conditions, the health effects in F344 rats following 2 yr of GVC or GMVC exposure were comparable in the production of renal adenomas and carcinomas in male rats and similar in other endpoints. |
| Databáze: | OpenAIRE |
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