Intracranial self-stimulation-reward induces neurite extension in PC12m3 cells and activation of the p38 MAPK pathway
| Autor: | Yoshihisa Koike, Naoya Sugiyama, Yoshihisa Kitamura, Yoshio Kano, Toshiaki Sendo, Hirotoshi Motoda, Yutaka Gomita, Satoru Esumi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Punishment (psychology) Neurite media_common.quotation_subject p38 mitogen-activated protein kinases Central nervous system Stimulation PC12 Cells p38 Mitogen-Activated Protein Kinases 03 medical and health sciences 0302 clinical medicine Self Stimulation Reward medicine Neurites Animals Emotional expression Bipolar disorder Rats Wistar media_common General Neuroscience Addiction Medial Forebrain Bundle medicine.disease Electric Stimulation Rats 030104 developmental biology medicine.anatomical_structure Psychology Neuroscience 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Neuroscience letters. 649 |
| ISSN: | 1872-7972 |
| Popis: | Factors that trigger emotional expression may be divided into two patterns according to the type of motivation, acquiring reward (pleasure) and avoiding aversion (punishment). Repeated exposure to certain external stimuli accompanied by aberrant motivation may produce psychiatric diseases such as bipolar disorder and addiction via dysregulation of the central nervous system. However, neurobiological underpinnings of such diseases have not been clarified, especially at the neuronal level. In the present study, plasma from rats undergoing intracranial self-stimulation (ICSS) produced neurite outgrowth in PC12-variant cells (PC12m3). Stimulated PC12m3 cells also exhibited heightened activity of the p38 MAPK pathway. These findings indicate that reward states lead to not only morphological changes but also increases in p38 MAPK activity at the neuronal level in the central nervous system. |
| Databáze: | OpenAIRE |
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