Human p21-activated kinase 5 (PAK5) expression and potential mechanisms in relevant cancers: Basic and clinical perspectives for molecular cancer therapeutics
| Autor: | Xi Zeng, Chang-ye Chen, Yukun Li, Ying Zeng, Dong-mei Ye, Gui-fang Luo, Juan Zou |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Breast cancer Mediator Neoplasms medicine Humans General Pharmacology Toxicology and Pharmaceutics Kinase business.industry Melanoma Cancer Matrix Attachment Region Binding Proteins General Medicine medicine.disease Hedgehog signaling pathway Gene Expression Regulation Neoplastic 030104 developmental biology p21-Activated Kinases Cancer research Osteosarcoma Female Ovarian cancer business Proto-Oncogene Proteins c-akt |
| Zdroj: | Life Sciences. 241:117113 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2019.117113 |
| Popis: | An oncogenic role, p21-activated kinase 5 (PAK5), has proven as a significant mediator for many cellular progression, which is expressed highly in human organs such as lung, liver, kidney, blood vessels endothelial cells and inflammatory cells. PAK5 was primitively detected in the cerebrum and accelerated the filopodia formation in neurocytes. It can reverse the effect of Rho and adjust its activity to mediate maintenance and development of nerve axon by binding with Cdc42-GTP. Moreover, PAK5 has been suggested to mediate protean, multitudinous and inscrutable functions in cancer. Currently, many researches indicated that PAK5 was dysregulated in ovarian cancer, cervical cancer, melanoma, osteosarcoma, renal carcinoma, breast cancer, gastric cancer and so on, which was involved in cell proliferation, apoptosis, migration and invasion. This review focuses the latest knowledge on the structure, expression, signalling pathway of PAK5, emphasizing its function in cancer. |
| Databáze: | OpenAIRE |
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