Changes in bone mineral density and bone metabolism after sleeve gastrectomy: a systematic review and meta-analysis
| Autor: | Patompong Ungprasert, Kornpong Vantanasiri, Sikarin Upala, Veeravich Jaruvongvanich |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Sleeve gastrectomy Adolescent medicine.medical_treatment Bariatric Surgery Parathyroid hormone 030209 endocrinology & metabolism medicine.disease_cause Gastroenterology Bone and Bones Bone remodeling Young Adult 03 medical and health sciences Postoperative Complications 0302 clinical medicine Bone Density Gastrectomy Internal medicine Weight Loss medicine Humans Femoral neck Bone mineral Gastric bypass surgery business.industry Confidence interval Obesity Morbid Surgery medicine.anatomical_structure Parathyroid Hormone Meta-analysis 030211 gastroenterology & hepatology business |
| Zdroj: | Surgery for Obesity and Related Diseases. 15:1252-1260 |
| ISSN: | 1550-7289 |
| Popis: | Background Roux-en-Y gastric bypass surgery adversely affects bone health. The evidence is less well-described for sleeve gastrectomy (SG). Objectives To better characterize bone metabolism changes after SG. Setting Systematic review and meta-analysis. Methods MEDLINE and EMBASE were searched through March 2019 for eligible studies assessing adults with obesity aged 18 years or older that underwent SG. Bone mineral density (BMD), serum calcium, serum phosphate, serum 25-hydroxyvitamin D, serum parathyroid hormone, or serum alkaline phosphatase were reported at baseline and after SG; and a follow-up duration was at least 6 months. Preoperative and postoperative mean of each outcome of interest and corresponding standard deviations were extracted from each study and the mean difference (MD) was calculated. Pooled MD was then calculated by combining MDs of each study using random-effects model. Results A total of 22 studies with 1905 patients with obesity that underwent SG were included. There were significant decreases in total hip BMD (pooled MD of −.06 g/cm2; 95% confidence interval −.09 to −.03; I2 = 0%) and femoral neck BMD (pooled MD of −.05 g/cm2; 95% confidence interval −.09 to −.02; I2 = 0%) after SG. No significant change in lumbar spine BMD was observed. There were significant increases in serum calcium, serum 25-hydroxyvitamin D, and serum phosphate. Serum parathyroid hormone was significantly decreased. Serum alkaline phosphatase was not significantly altered after SG. Conclusions The present study found a decreased BMD among patients with obesity after SG. |
| Databáze: | OpenAIRE |
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