Alterations in calcium, magnesium, iron, and zinc metabolism by dietary cholestyramine
| Autor: | Don W. Watkins, G. V. Vahouny, Reza Khalafi, Marie M. Cassidy |
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| Rok vydání: | 1985 |
| Předmět: |
Male
medicine.medical_specialty Physiology Iron Cholestyramine Resin chemistry.chemical_element Parathyroid hormone Calcium Intestinal absorption Feces Internal medicine medicine Animals Magnesium Intestinal Mucosa Calcium metabolism Osteomalacia Cholestyramine Chemistry Spectrophotometry Atomic Feces analysis Gastroenterology Rats Inbred Strains Hydrogen-Ion Concentration medicine.disease Rats Calcium Dietary Zinc Endocrinology medicine.drug |
| Zdroj: | Digestive diseases and sciences. 30(5) |
| ISSN: | 0163-2116 |
| Popis: | Cholestyramine is an effective drug for the reduction of plasma cholesterol because of its ability to sequester intestinal bile acids. Since metabolic alterations, including diminished intestinal absorption of vitamin D and osteomalacia have been reported with long-term use of this resin, the influence of cholestyramine on dietary balance of four mineral elements has been investigated. Wistar-strain rats were fed either a 2% cholestyramine or control diet for one month. Dietary intakes and fecal and urinary excretions of calcium, magnesium, iron, and zinc were determined using atomic absorption spectrophotometry during three, 3-day balance periods. Cholestyramine-fed rats had a net negative balance for calcium and a lower net positive balance for magnesium, iron, and zinc than the controls. Other effects of cholestyramine were an increased urinary excretion of calcium and magnesium, a decreased urinary zinc, and an alkalinization of urine. Blood and tissue cation content was unchanged except for a reduction in serum magnesium with resin feeding. Alterations in calcium, magnesium, and zinc metabolism might be explained by inadequate vitamin D absorption from the intestine followed by an increased secretion of parathyroid hormone. A diminished iron absorption due to resin binding could account for the reported disturbance in iron balance. |
| Databáze: | OpenAIRE |
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