Advancing antimicrobial strategies for managing oral biofilm infections
| Autor: | Franklin R. Tay, Ji Hua Chen, Yang Jiao, Li Na Niu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Increased drug tolerance Preventive dentistry Review Article 02 engineering and technology 03 medical and health sciences Anti-Infective Agents medicine Humans Intensive care medicine General Dentistry Mouth business.industry Biofilm Bacterial Infections Plankton 021001 nanoscience & nanotechnology Antimicrobial Infection control in dentistry Anti-Bacterial Agents Clinical Practice lcsh:RK1-715 030104 developmental biology Biofilms lcsh:Dentistry 0210 nano-technology business |
| Zdroj: | International Journal of Oral Science, Vol 11, Iss 3, Pp 1-11 (2019) International Journal of Oral Science |
| ISSN: | 2049-3169 1674-2818 |
| Popis: | Effective control of oral biofilm infectious diseases represents a major global challenge. Microorganisms in biofilms exhibit increased drug tolerance compared with planktonic cells. The present review covers innovative antimicrobial strategies for controlling oral biofilm-related infections published predominantly over the past 5 years. Antimicrobial dental materials based on antimicrobial agent release, contact-killing and multi-functional strategies have been designed and synthesized for the prevention of initial bacterial attachment and subsequent biofilm formation on the tooth and material surface. Among the therapeutic approaches for managing biofilms in clinical practice, antimicrobial photodynamic therapy has emerged as an alternative to antimicrobial regimes and mechanical removal of biofilms, and cold atmospheric plasma shows significant advantages over conventional antimicrobial approaches. Nevertheless, more preclinical studies and appropriately designed and well-structured multi-center clinical trials are critically needed to obtain reliable comparative data. The acquired information will be helpful in identifying the most effective antibacterial solutions and the most optimal circumstances to utilize these strategies. |
| Databáze: | OpenAIRE |
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