Long-term memory for aversive training is impaired in Idua−/− mice, a genetic model of mucopolysaccharidosis type I
| Autor: | Gustavo Kellermann Reolon, Melissa Camassola, Rafael Roesler, Nance Beyer Nardi, Tatiana Luft, João Antonio Pêgas Henriques, Luisa Maria Gomes de Macedo Braga |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pore Forming Cytotoxic Proteins medicine.medical_specialty Mucopolysaccharidosis I Statistics Nonparametric Open field Mice Mucopolysaccharidosis type I Memory Internal medicine Genetic model Neuroplasticity Avoidance Learning Reaction Time medicine Lysosomal storage disease Animals Molecular Biology Mice Knockout Electroshock Behavior Animal Long-term memory General Neuroscience Memoria Neurodegeneration Membrane Proteins Recognition Psychology medicine.disease Mice Inbred C57BL Disease Models Animal Inhibition Psychological Endocrinology Exploratory Behavior Neurology (clinical) Psychology Neuroscience Developmental Biology |
| Zdroj: | Brain Research. 1076:225-230 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2006.01.008 |
| Popis: | Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease that leads to neurodegeneration and neurological deficits, among other pathological and clinical consequences. The aim of the present study was to evaluate neurobehavioral parameters in a genetic mouse model of mucopolysaccharidosis type I (MPS I). During exploration of an open field, adult MPS I ( Idua −/− ) mice showed normal locomotion and anxiety but reduced number of rearings. Idua −/− mice performed normally in a novel object recognition memory task and showed normal short-term retention of inhibitory avoidance training. By contrast, long-term retention of inhibitory avoidance was impaired in Idua −/− mice. The deficit in inhibitory avoidance memory could not be attributed to reduced footshock reactivity. The results indicate that Idua −/− mice present deficits in long-term memory for aversive training and reduced exploratory behavior. |
| Databáze: | OpenAIRE |
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