Small-caliber vascular grafts based on a piezoelectric nanocomposite elastomer: Mechanical properties and biocompatibility
| Autor: | Ilaria Bice Di Cioccio, Paola Losi, A. Cafarelli, Leonardo Ricotti, Alice Rita Salgarella, Ilenia Foffa, Lorenzo Vannozzi, Maria Chiara Barsotti, Giorgio Soldani, Pasqualantonio Pingue |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Biocompatibility Barium Compounds Biomedical Engineering Nanoparticle Modulus Semi-interpenetrating polymeric network Biocompatible Materials 02 engineering and technology Vascular graft Elastomer Piezoelectric material Prosthesis Design Nanocomposites Biomaterials 03 medical and health sciences 0302 clinical medicine Electricity Elastic Modulus Tensile Strength Ultimate tensile strength Pressure Barium titanate nanoparticles Humans Saphenous Vein Composite material Porosity Titanium Nanocomposite Tissue Scaffolds Flexural rigidity 030206 dentistry Fibroblasts 021001 nanoscience & nanotechnology Spray deposition Elastomers Mechanics of Materials Barium titanate nanoparticlesSpray deposition Nanoparticles Vascular Grafting Stress Mechanical 0210 nano-technology |
| Zdroj: | Journal of the mechanical behavior of biomedical materials 97 (2019): 138–148. doi:10.1016/j.jmbbm.2019.05.017 info:cnr-pdr/source/autori:Cafarelli, Andrea; Losi, Paola; Salgarella, Alice Rita; Barsotti, Maria Chiara; Di Cioccio, Ilaria Bice; Foffa, Ilenia; Vannozzi, Lorenzo; Pingue, Pasqualantonio; Soldani, Giorgio; Ricotti, Leonardo/titolo:Small-caliber vascular grafts based on a piezoelectric nanocomposite elastomer: Mechanical properties and biocompatibility/doi:10.1016%2Fj.jmbbm.2019.05.017/rivista:Journal of the mechanical behavior of biomedical materials (Print)/anno:2019/pagina_da:138/pagina_a:148/intervallo_pagine:138–148/volume:97 |
| ISSN: | 1878-0180 |
| Popis: | The development of small-caliber grafts still represents a challenge in the field of vascular prostheses. Among other factors, the mechanical properties mismatch between natural vessels and artificial devices limits the efficacy of state-of-the-art materials. In this paper, a novel nanocomposite graft with an internal diameter of 6 mm is proposed. The device is obtained through spray deposition using a semi-interpenetrating polymeric network combining poly(ether)urethane and polydimethilsyloxane. The inclusion of BaTiO3 nanoparticles endows the scaffold with piezoelectric properties, which may be exploited in the future to trigger beneficial biological effects. Graft characterization demonstrated a good nanoparticle dispersion and an overall porosity that was not influenced by the presence of nanoparticles. Graft mechanical properties resembled (or even ameliorated) the ones of natural vessels: both doped and non-doped samples showed a Young's modulus of ∼700 kPa in the radial direction and ∼900 kPa in the longitudinal direction, an ultimate tensile strength of ∼1 MPa, a strain to failure of ∼700%, a suture retention force of ∼1.7 N and a flexural rigidity of ∼2.5 × 10−5 N m2. The two grafts differed in terms of burst strength that resulted ∼800 kPa for the control non-doped samples and ∼1100 kPa for the doped ones. The graft doped with BaTiO3 nanoparticles showed a d33 coefficient of 1.91 pm/V, almost double than the non-doped control. The device resulted highly stable, with a mass loss smaller than 2% over 3 months and an excellent biocompatibility. |
| Databáze: | OpenAIRE |
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