Histological Features and Tissue Microarray Taxonomy of Nigerian Breast Cancer Reveal Predominance of the High-Grade Triple-Negative Phenotype

Autor:	Akinwunmi O. Komolafe, Yalda Alizadeh, D Pathak, O A Adeoye, Omoniyi-Esan Go, A Foster, Adewale O. Adisa, A Manoharan, Adetola Daramola, Paul D. Lewis, M N D'Cruz, N A Titloye, Abeer M Shaaban
Rok vydání:	2016
Předmět:	Adult 0301 basic medicine Pathology medicine.medical_specialty Receptor ErbB-2 Nigeria Estrogen receptor Breast Neoplasms Triple Negative Breast Neoplasms Biology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Breast cancer Progesterone receptor Biomarkers Tumor medicine Carcinoma Humans Molecular Biology Tissue microarray Age Factors Histology Cell Biology General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Androgen receptor Phenotype 030104 developmental biology Receptors Estrogen Receptors Androgen Tissue Array Analysis 030220 oncology & carcinogenesis Keratins Female Receptors Progesterone
Zdroj:	Pathobiology. 83:24-32
ISSN:	1423-0291 1015-2008
Popis:	Introduction: Little is known about the biology, molecular profile and hence optimal treatment of African Nigerian breast cancer. The aim of this work, therefore, was to characterize the histology and molecular profile of Nigerian breast cancer. Methods: Breast carcinomas from women at 6 centres of similar tribal origin in Nigeria were reviewed and assembled into tissue microarrays (TMAs), and sections were stained for hormone receptors, i.e. estrogen receptor (ER)α, ERβ1, ERβ progesterone receptor (PR) and androgen receptor, cyclin D, HER2, Ki67 and cytokeratins (CKs), i.e. CK5/6 and CK14 (basal) and CK18 and 19 (luminal). Results: A total of 835 tumours were analysed. The mean age at diagnosis was 48.62 ± 12.41 years. The most common histological subtype was ductal NST (no-special-type) carcinoma (87.3%). Over 90% of the tumours were grade 2 or 3. The predominant molecular phenotype was the non-basal, triple-negative type (47.65%) followed by the HER2-positive group (19.6%). The percentage of ER-, PR- and HER2-positive tumours was 22.4, 18.9 and 18.8%, respectively. Conclusion: Nigerian breast cancer predominantly has a high-grade, triple-negative profile. It occurs at a younger age and bears similarities at the molecular level to pre-menopausal breast cancer in white women, with remarkably lower levels of ERβ expression. The early presentation and histological and molecular phenotype may explain the poor prognosis, and tailoring treatment strategies to target this unique profile are required.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231548da13c27fcaa8dacb56d4a82059 https://doi.org/10.1159/000441949 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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