Maternal use of dietary supplements during pregnancy is not associated with coeliac disease in the offspring: The Environmental Determinants of Diabetes in the Young (TEDDY) study
| Autor: | Marian Rewers, Jorma Toppari, Carin Andrén Aronsson, Jeffrey P. Krischer, Roy N. Tamura, William Hagopian, Jimin Yang, Daniel Agardh, Jill M. Norris, Beena Akolkar, Ulla Uusitalo, Anette-G. Ziegler, Jin-Xiong She, Åke Lernmark, Suvi M. Virtanen |
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| Jazyk: | němčina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Offspring Iron The Environmental Determinants of Diabetes in the Young Medicine (miscellaneous) Autoimmunity 030209 endocrinology & metabolism Article Coeliac disease 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Fatty Acids Omega-3 Cda Coeliac Disease Autoimmunity Fa Fatty Acids Hla Human Leucocyte Antigen Hr Hazard Ratio Teddy The Environmental Determinants Of Diabetes In The Young Ttga Tissue Transglutaminase Antibodies Coeliac Disease Dietary Supplements Maternal Vitamin D and neurology Humans Medicine Micronutrients 030212 general & internal medicine Vitamin D Child Prenatal Nutritional Physiological Phenomena Proportional Hazards Models Nutrition and Dietetics business.industry ta3141 ta3121 Micronutrient medicine.disease ta3123 Celiac Disease Endocrinology Female business Breast feeding Postpartum period |
| Zdroj: | Br. J. Nutr. 117, 466-472 (2017) |
| Popis: | Perinatal exposure to nutrients and dietary components may affect the risk for coeliac disease (CD). We investigated the association between maternal use of vitamin D, n-3 fatty acids (FA) and Fe supplements during pregnancy and risk for CD autoimmunity (CDA) and CD in the offspring. Children at increased genetic risk were prospectively followed from birth in The Environmental Determinants of Diabetes in the Young (TEDDY) study. CDA was defined as having persistently positive tissue transglutaminase autoantibodies (tTGA). Diagnosis of CD was either biopsy-confirmed or considered likely if having persistently elevated levels of tTGA>100 AU. Of 6627 enrolled children, 1136 developed CDA at a median 3·1 years of age (range 0·9–10) and 409 developed CD at a median 3·9 years of age (range 1·2–11). Use of supplements containing vitamin D, n-3 FA and Fe was recalled by 66, 17 and 94 % of mothers, respectively, at 3–4 months postpartum. The mean cumulative intake over the entire pregnancy was 2014 μg vitamin D (sd 2045 μg), 111 g n-3 FA (sd 303 g) and 8806 mg Fe (sd 7017 mg). After adjusting for country, child’s human leucocyte antigen genotype, sex, family history of CD, any breast-feeding duration and household crowding, Cox’s proportional hazard ratios did not suggest a statistically significant association between the intake of vitamin D, n-3 FA or Fe, and risk for CDA or CD. Dietary supplementation during pregnancy may help boost nutrient intake, but it is not likely to modify the risk for the disease in the offspring. |
| Databáze: | OpenAIRE |
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