Effects of intraocular cefotaxime on the human corneal endothelium
| Autor: | Manfred Haber, Oliver Schwenn, Gerhard Hommel, Christina Kramann, Norbert Pfeiffer, Susanne Pitz |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Corneal endothelium Cefotaxime Anterior Chamber medicine.medical_treatment Cell Count Intraocular lens Balanced salt solution Double-Blind Method Lens Implantation Intraocular Cornea Ophthalmology medicine Humans Prospective Studies Aged Cell Size Antibacterial agent Aged 80 and over Endophthalmitis Phacoemulsification business.industry Endothelium Corneal Middle Aged Sensory Systems Cephalosporins Endothelial stem cell medicine.anatomical_structure Female Surgery sense organs business medicine.drug |
| Zdroj: | Journal of Cataract and Refractive Surgery. 27:250-255 |
| ISSN: | 0886-3350 |
| DOI: | 10.1016/s0886-3350(00)00474-0 |
| Popis: | Purpose To ascertain whether 0.4 mL of cefotaxime 0.25% applied intracamerally causes toxic alteration of the human corneal endothelium. Methods In this prospective randomized masked study, 66 patients had cataract extraction using phacoemulsification, a frown incision, and implantation of a poly(methyl methacrylate) intraocular lens. This was followed by intraocular injection of 0.4 mL of cefotaxime 0.25% or balanced salt solution (BSS®). Contact specular microscopy and photography were performed preoperatively and 1 to 4 days and 3 months postoperatively. Results In the cefotaxime group, the mean endothelial cell count was 2729 cells/mm 2 ± 474 (SD) preoperatively, 2520 ± 462 cells/mm 2 1 to 4 days postoperatively, and 2560 ± 495 cells/mm 2 3 months postoperatively. The mean endothelial cell count in the BSS (control) group was 2657 ± 413 cells/mm 2 , 2475 ± 384 cells/mm 2 , and 2486 ± 427 cells/mm 2 , respectively. There was no significant difference in cell count or morphology between groups ( P Conclusions Intraocular application of cefotaxime produced no significant changes in endothelial cell count or morphology when compared with application of a control substance. With its broad spectrum of antibiotic activity, cefotaxime might be an appropriate alternative to other intraocularly administered antibiotics in anterior segment surgery for prophylaxis and management of infection. |
| Databáze: | OpenAIRE |
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