Correlation of Nasal Fluid Biomarkers and Symptoms in Patients with Persistent Allergic Rhinitis
| Autor: | Jeon Gang Doo, Young-Gyu Eun, Su Il Kim, Sung Wan Kim, Jin Young Min, Young Chan Lee, Oh Eun Kwon, Jung Min Park, Seok Hyun Kim, Hae Rim Jung |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Enzyme-Linked Immunosorbent Assay Gastroenterology Severity of Illness Index Sneezing Young Adult Internal medicine medicine Humans Uteroglobin In patient Nasal fluid business.industry Pruritus General Medicine Middle Aged Nasal Lavage Fluid Rhinitis Allergic Otorhinolaryngology Clara cell protein 16 Biomarker (medicine) Female Tryptases Interleukin-5 Nasal Obstruction business Biomarkers |
| Zdroj: | The Annals of otology, rhinology, and laryngology. 129(6) |
| ISSN: | 1943-572X |
| Popis: | Objectives: This study investigated whether the biomarkers present in nasal fluid reflect the severity of symptoms in patients with persistent allergic rhinitis (PAR). Methods: We enrolled 29 PAR patients complaining of nasal symptoms and testing positive to skin prick test. Patients’ total nasal symptom score (TNSS) was measured and their nasal lavage fluid (NALF) was collected. The levels of biomarkers including Clara cell protein 16 (CC16), tryptase, and interleukin 5 (IL-5) in NALF were determined via enzyme-linked immunosorbent assay (ELISA). Results: PAR patients were classified into persistent mild and persistent moderate-to-severe groups according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. The CC16 alone was significantly negatively correlated with TNSS ( P Conclusions: The levels of CC16 alone among several NALF biomarkers showed an inverse correlation with symptoms of PAR patients. |
| Databáze: | OpenAIRE |
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