Impact of Circadian Disruption on Female Mice Reproductive Function
| Autor: | Valérie Simonneaux, Mathilda Kretz, Thibault Bahougne, Eleni Angelopoulou, Nathalie Jeandidier |
|---|---|
| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Les Hôpitaux Universitaires de Strasbourg (HUS) |
| Rok vydání: | 2020 |
| Předmět: |
Circadian disruption
Estrous cycle 0303 health sciences medicine.medical_specialty Reproductive function media_common.quotation_subject 030209 endocrinology & metabolism Fertility Biology Oocyte [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology 03 medical and health sciences 0302 clinical medicine Endocrinology medicine.anatomical_structure 13. Climate action Internal medicine medicine Gestation Luteinizing hormone Reproductive effects 030304 developmental biology media_common |
| Zdroj: | Endocrinology Endocrinology, Oxford University Press, 2020, 161 (4), pp.bqaa028. ⟨10.1210/endocr/bqaa028⟩ |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endocr/bqaa028 |
| Popis: | In female mammals, cycles in reproductive function depend both on the biological clock synchronized to the light/dark cycle and on a balance between the negative and positive feedbacks of estradiol, whose concentration varies during oocyte maturation. In women, studies report that chronodisruptive environments such as shiftwork may impair fertility and gestational success. The objective of this study was to explore the effects of shifted light/dark cycles on both the robustness of the estrous cycles and the timing of the preovulatory luteinizing hormone (LH) surge in female mice. When mice were exposed to a single 10-hour phase advance or 10-hour phase delay, the occurrence and timing of the LH surge and estrous cyclicity were recovered at the third estrous cycle. By contrast, when mice were exposed to chronic shifts (successive rotations of 10-hoursour phase advances for 3 days followed by 10-hour phase delays for 4 days), they exhibited a severely impaired reproductive activity. Most mice had no preovulatory LH surge at the beginning of the chronic shifts. Furthermore, the gestational success of mice exposed to chronic shifts was reduced, because the number of pups was 2 times lower in shifted than in control mice. In conclusion, this study reports that exposure of female mice to a single phase shift has minor reproductive effects, whereas exposure to chronically disrupted light/dark cycles markedly impairs the occurrence of the preovulatory LH surge, leading to reduced fertility. |
| Databáze: | OpenAIRE |
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