Inhibition of mitochondrial complex II alters striatal expression of genes involved in glutamatergic and dopaminergic signaling: possible implications for Huntington's disease

Autor: Alberto Gulino, Silvia Rossi, Maddalena Napolitano, Giorgio Bernardi, Stefania Spiezia, Paolo Gubellini, Paolo Calabresi, Diego Centonze
Rok vydání: 2004
Předmět:
Enzymologic
Dopamine
Wistar
Striatum
Enzyme Inhibitors
Oligonucleotide Array Sequence Analysis
3-Nitropropionic acid
Electron Transport Complex II
Dopaminergic
Neurodegeneration
Huntington's disease
Protein-Serine-Threonine Kinases
Nitro Compounds
Propionic Acids
Succinate Dehydrogenase
Phosphoric Monoester Hydrolases
Phosphoproteins
Rats
Wistar
Rats
Neostriatum
Animals
Huntington Disease
Glutamic Acid
Signal Transduction
Nerve Tissue Proteins
Dopamine and cAMP-Regulated Phosphoprotein 32
Gene Expression Regulation
Enzymologic
Neurology
Basal ganglia
Settore MED/26 - Neurologia
Signal transduction
medicine.drug
In Vitro Techniques
Protein Serine-Threonine Kinases
Biology
lcsh:RC321-571
Glutamatergic
medicine
Protein kinase A
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
3-nitropropionic acid
animals
antagonists /&/ inhibitors/drug effects/physiology
antagonists /&/ inhibitors/metabolism
basal ganglia
cdna microarrays
darpp-32
dopamine
dopamine and camp-regulated phosphoprotein 32
drug effects/genetics
drug effects/metabolism
drug effects/metabolism/physiopathology
electron transport complex ii
enzyme inhibitors
enzymologic
gene expression regulation
genetics/metabolism
genetics/metabolism/physiopathology
glutamic acid
huntington disease
huntington's disease
neostriatum
nerve tissue proteins
nitro compounds
oligonucleotide array sequence analysis
pharmacology
phosphoproteins
phosphoric monoester hydrolases
propionic acids
protein-serine-threonine kinases
rats
signal transduction
succinate dehydrogenase
wistar
medicine.disease
DARPP-32
Gene Expression Regulation
Propionates
Neuroscience
cDNA microarrays
Zdroj: Neurobiology of Disease, Vol 15, Iss 2, Pp 407-414 (2004)
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2003.11.021
Popis: Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by motor abnormalities and cognitive impairment. The irreversible succinate dehydrogenase (SD) inhibitor 3-nitropropionic acid (3NP) causes neurodegeration in the striatum resembling HD when administered to rodents or primates. Using corticostriatal brain slice preparations, we analyzed the pattern of gene expression following 3NP application utilizing cDNA microarrays. Acute 3NP treatment modulates the expression of several genes involved in dopaminergic and glutamatergic signaling in corticostriatal brain slices, and unbalances the downstream serine/threonine protein kinase and phosphatase network affecting the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32). Our data provide new information about the molecular events possibly underlying neurodegeneration induced by this mitochondrial toxin.
Databáze: OpenAIRE
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