Immune microenvironment in Barrett’s esophagus adjacent to esophageal adenocarcinoma: possible influence of adjacent mucosa on cancer development and progression
| Autor: | Nobuhisa Yajima, Yusuke Gokon, Kazutomi Takahashi, Takashi Sawai, Motohisa Hagiwara, Fumiyoshi Fujishima, Yusuke Taniyama, Masashi Zuguchi, Tsutomu Sakuma, Takashi Kamei, Akiko Nishida, Rikiya Kanba, Hironobu Sasano, Yuko Itakura, Miwa Uzuki, Hirofumi Ichikawa, Yohei Ozawa, Taku Yamagata, Masahiro Saito, Hirotaka Ishida, Kazuhiro Sakamoto |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Esophageal Mucosa Esophageal Neoplasms Lymphocyte Adenocarcinoma Pathology and Forensic Medicine Barrett Esophagus 03 medical and health sciences 0302 clinical medicine Immune system Tumor Microenvironment Humans Medicine Esophagus Molecular Biology Aged Lamina propria business.industry FOXP3 Cell Biology General Medicine Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure Dysplasia 030220 oncology & carcinogenesis Barrett's esophagus Disease Progression Cancer research Female business CD8 |
| Zdroj: | Virchows Archiv. 477:825-834 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-020-02854-0 |
| Popis: | The immune microenvironment plays a pivotal role in cancer development and progression. Therefore, we studied the status of immune cells in esophageal adenocarcinoma (EAC) and adjacent Barrett's esophagus (BE) and their association with the clinical course of patients. We included 87 patients with EAC who underwent surgical resection or endoscopic submucosal dissection. CD3, CD8, Foxp3, p53, and Ki-67 were immunolocalized in EAC and adjacent BE (N = 87) and BE without EAC (N = 13). BE adjacent to EAC exhibited higher CD3+ lamina propria lymphocyte (LPL) numbers than BE without EAC. Abundant Foxp3+ LPLs in BE were associated with dysplasia and increased Ki-67 labeling index (LI) in BE glandular cells and tended to link to aberrant p53 expression. Abundant CD8+ LPLs in adjacent BE were associated with worse prognosis of EAC patients (P = 0.019). Results of our present study firstly revealed the potential influence of the tissue immune microenvironment of BE adjacent to EAC on cancer development and eventual clinical outcome of EAC patients. T cell infiltration could play pivotal roles in facilitating the dysplasia-adenocarcinoma sequence in BE. The number of Foxp3+ T cells is increased at the early stage of carcinogenesis and could help identify patients harboring dysplastic and highly proliferating cells. CD8+ T cells could reflect unfavorable inflammatory response in adjacent tissue microenvironment and help predict worse prognosis of EAC patients. |
| Databáze: | OpenAIRE |
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