Decreased renal function is associated with incident dementia: An IMRD-THIN retrospective cohort study in the UK
| Autor: | Siang Ing Lee, Jennifer Cooper, Anthony Fenton, Anuradhaa Subramanian, Tom Taverner, Krishna M. Gokhale, Katherine Phillips, Mitesh Patel, Lorraine Harper, G. Neil Thomas, Krishnarajah Nirantharakumar |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Epidemiology Health Policy Kidney United Kingdom Cohort Studies Psychiatry and Mental health Cellular and Molecular Neuroscience Developmental Neuroscience Risk Factors Creatinine Albumins Humans Dementia Neurology (clinical) Geriatrics and Gerontology Renal Insufficiency Chronic Retrospective Studies |
| Zdroj: | Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES. 18(10) |
| ISSN: | 1552-5279 |
| Popis: | Decreased renal function is a potential risk factor for dementia.This retrospective cohort study of 2.8 million adults aged ≥50 years used the IMRD-THIN database, representative of UK primary care, from January 1, 1995 to February 24, 2020. The associations between estimated glomerular filtration rate (eGFR) and urine albumin creatinine ratio (ACR) with incident all-cause dementia were analyzed using Cox regression.In the eGFR cohort (n = 2,797,384), worsening renal dysfunction was associated with increased hazard of all-cause dementia, with greatest hazard at eGFR 15-30 ml/min/1.73minWorsening eGFR and albuminuria have graded associations with the risk of dementia, which may have significant implications for the care of patients with kidney disease. |
| Databáze: | OpenAIRE |
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